MFAP4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation
Arterial injury stimulates remodeling responses that, when excessive, lead to stenosis. These responses are influenced by integrin signaling in vascular smooth muscle cells (VSMCs). Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vasc...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Arteriosclerosis, thrombosis, and vascular biology
Year: 2016, Volume: 36, Issue: 1, Pages: 122-133 |
| ISSN: | 1524-4636 |
| DOI: | 10.1161/ATVBAHA.115.306672 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/ATVBAHA.115.306672 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306672 |
| Author Notes: | Anders Schlosser, Bartosz Pilecki, Line E. Hemstra, Karin Kejling, Gudlaug B. Kristmannsdottir, Helle Wulf-Johansson, Jesper B. Moeller, Ernst-Martin Füchtbauer, Ole Nielsen, Katrine Kirketerp-Møller, Lalit K. Dubey, Pernille B.L. Hansen, Jane Stubbe, Christoph Wrede, Jan Hegermann, Matthias Ochs, Birgit Rathkolb, Anja Schrewe, Raffi Bekeredjian, Eckhard Wolf, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Jes S. Lindholt, Uffe Holmskov, Grith L. Sorensen |
| Summary: | Arterial injury stimulates remodeling responses that, when excessive, lead to stenosis. These responses are influenced by integrin signaling in vascular smooth muscle cells (VSMCs). Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vascular wall. The role of MFAP4 in vascular biology is unknown. We aimed to test the hypothesis that MFAP4 would enhance integrin-dependent VSMC activation. |
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| Item Description: | Originally published 12 Nov 2015 Gesehen am 15.05.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1524-4636 |
| DOI: | 10.1161/ATVBAHA.115.306672 |