Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Objective: The aim of the study was to analyze the effect of thymectomy on the proposed disease-specific microRNA (miRNA) biomarkers miR-150-5p and miR-21-5p in patients from the prospective randomized trial of thymectomy in myasthenia gravis (MGTX trial) and to evaluate the longitudinal changes in...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 1, 2018
|
| In: |
Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
Year: 2018, Jahrgang: 5, Heft: 3 |
| ISSN: | 2332-7812 |
| DOI: | 10.1212/NXI.0000000000000450 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1212/NXI.0000000000000450
|
| Verfasserangaben: | Carl Johan Molin, Liis Sabre, Cleo-Aron Weis, Tanel Punga, Anna Rostedt Punga |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698317786 | ||
| 003 | DE-627 | ||
| 005 | 20230427073145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200515s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1212/NXI.0000000000000450 |2 doi | |
| 035 | |a (DE-627)1698317786 | ||
| 035 | |a (DE-599)KXP1698317786 | ||
| 035 | |a (OCoLC)1341324970 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Molin, Carl Johan |e VerfasserIn |0 (DE-588)1210277360 |0 (DE-627)1698318820 |4 aut | |
| 245 | 1 | 0 | |a Thymectomy lowers the myasthenia gravis biomarker miR-150-5p |c Carl Johan Molin, Liis Sabre, Cleo-Aron Weis, Tanel Punga, Anna Rostedt Punga |
| 264 | 1 | |c March 1, 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.05.2020 | ||
| 520 | |a Objective: The aim of the study was to analyze the effect of thymectomy on the proposed disease-specific microRNA (miRNA) biomarkers miR-150-5p and miR-21-5p in patients from the prospective randomized trial of thymectomy in myasthenia gravis (MGTX trial) and to evaluate the longitudinal changes in clinical patterns compared with these miRNA levels. - Methods: Serum samples were obtained from 80 patients with MG who were included in the MGTX trial. Thirty-eight patients were randomized to thymectomy plus prednisone treatment, and 42 patients were randomized to prednisone treatment. Serum samples were analyzed for the expression of miR-150-5p and miR-21-5p, with quantitative reverse transcriptase PCR at baseline and at 12, 24, and 36 months after randomization. The inclusion criteria for participation in the MGTX trial were age 18-65 years, generalized myasthenia gravis (Myasthenia Gravis Foundation of America Class II-IV), disease duration of less than 5 years, and seropositivity for acetylcholine receptor antibodies (AChR+). - Results: Patients treated with thymectomy had lower levels of miR-150-5p at 24 months, both compared with baseline values (p = 0.0011) and the prednisone group (p = 0.04). No change in miRNA levels was found in the prednisone group. Levels of miR-21-5p displayed a negative correlation with the prednisone dose within the prednisone-only group (p ≤ 0.001). - Conclusions: Thymectomy lowers the levels of the proposed biomarker miR-150-5p, which strengthens its position as a potential disease-specific biomarker for AChR+ MG. | ||
| 700 | 1 | |a Sabre, Liis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 700 | 1 | |a Punga, Tanel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Punga, Anna Rostedt |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology |d Philadelphia, Pa. : Wolters Kluwer, 2014 |g 5(2018,3) Artikel-Nummer e450, 9 Seiten |h Online-Ressource |w (DE-627)784191956 |w (DE-600)2767740-0 |w (DE-576)404866883 |x 2332-7812 |7 nnas |a Thymectomy lowers the myasthenia gravis biomarker miR-150-5p |
| 773 | 1 | 8 | |g volume:5 |g year:2018 |g number:3 |g extent:9 |a Thymectomy lowers the myasthenia gravis biomarker miR-150-5p |
| 856 | 4 | 0 | |u https://doi.org/10.1212/NXI.0000000000000450 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200515 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ |p 3 | ||
| 999 | |a KXP-PPN1698317786 |e 3667343582 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"title":[{"title":"Thymectomy lowers the myasthenia gravis biomarker miR-150-5p","title_sort":"Thymectomy lowers the myasthenia gravis biomarker miR-150-5p"}],"relHost":[{"recId":"784191956","id":{"eki":["784191956"],"issn":["2332-7812"],"zdb":["2767740-0"]},"note":["Gesehen am 28.04.14"],"pubHistory":["1.2014 -"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Wolters Kluwer ; Lippincott Williams & Wilkins","publisherPlace":"Philadelphia, Pa. ; Philadelphia, Pa.","dateIssuedKey":"2014","dateIssuedDisp":"2014-"}],"title":[{"title_sort":"Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology","title":"Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology"}],"language":["eng"],"part":{"text":"5(2018,3) Artikel-Nummer e450, 9 Seiten","extent":"9","volume":"5","year":"2018","issue":"3"},"disp":"Thymectomy lowers the myasthenia gravis biomarker miR-150-5pNeurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology","type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedDisp":"March 1, 2018","dateIssuedKey":"2018"}],"name":{"displayForm":["Carl Johan Molin, Liis Sabre, Cleo-Aron Weis, Tanel Punga, Anna Rostedt Punga"]},"person":[{"given":"Carl Johan","family":"Molin","roleDisplay":"VerfasserIn","display":"Molin, Carl Johan","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Sabre, Liis","role":"aut","family":"Sabre","given":"Liis"},{"role":"aut","display":"Weis, Cleo-Aron Thias","roleDisplay":"VerfasserIn","family":"Weis","given":"Cleo-Aron Thias"},{"role":"aut","display":"Punga, Tanel","roleDisplay":"VerfasserIn","family":"Punga","given":"Tanel"},{"family":"Punga","given":"Anna Rostedt","role":"aut","display":"Punga, Anna Rostedt","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"9 S."}],"note":["Gesehen am 14.05.2020"],"id":{"doi":["10.1212/NXI.0000000000000450"],"eki":["1698317786"]},"recId":"1698317786"} | ||
| SRT | |a MOLINCARLJTHYMECTOMY1201 | ||