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Expression of semaphorin class 3 is higher in the proliferative phase on the human endometrium

Purpose: The semaphorins are related to angiogenesis and cell proliferation depending on the tissue. The purpose of this study was to assess gene expression of class 3 semaphorin (SEMA3A-F) and protein expression of semaphorin 3A (SEMA3A) within human endometrium throughout the menstrual cycle. Meth...

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Bibliographic Details
Main Authors: Ferreira, Gustavo Dias (Author) , Capp, Edison (Author) , Jauckus, Julia (Author) , Strowitzki, Thomas (Author) , Germeyer, Ariane (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2018
In: Archives of gynecology and obstetrics
Year: 2018, Volume: 297, Issue: 5, Pages: 1175-1179
ISSN:1432-0711
DOI:10.1007/s00404-018-4719-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00404-018-4719-3
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Author Notes:Gustavo Dias Ferreira, Edison Capp, Julia Jauckus, Thomas Strowitzki, Ariane Germeyer
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Summary:Purpose: The semaphorins are related to angiogenesis and cell proliferation depending on the tissue. The purpose of this study was to assess gene expression of class 3 semaphorin (SEMA3A-F) and protein expression of semaphorin 3A (SEMA3A) within human endometrium throughout the menstrual cycle. Methods: Gene expression of SEMA3A-F was analyzed by real-time PCR (qRT-PCR) and protein expression of SEMA3A was analyzed by ELISA in endometrial biopsies in the proliferative and secretory phase of the menstrual cycle. Results: Gene expression of SEMA3A, SEMA3C, SEMA3D, and SEMA3E was statistically significant decreased in secretory compared to proliferative phase endometrium (p < 0.05). Accordingly, SEMA3A protein expression in the secretory phase was lower than protein expression in proliferative phase endometrium (p ≤ 0.05). Conclusion: SEMA3A, 3C, 3D, and 3E are possibly related to cell proliferation in the endometrium, being more expressed in the proliferative phase of the cycle. This finding may stimulate studies of class 3 semaphorins as a possible target for treatment of endometrial pathologies.
Item Description:Gesehen am 19.05.2020
Physical Description:Online Resource
ISSN:1432-0711
DOI:10.1007/s00404-018-4719-3

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