Redox sensitivity of the MyD88 immune signaling adapter
The transcription factor nuclear factor-κB (NF-κB) mediates expression of key genes involved in innate immunity and inflammation. NF-κB activation has been repeatedly reported to be modulated by hydrogen peroxide (H2O2). Here, we show that the NF-κB-activating signaling adapter myeloid differentiati...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 October 2016
|
| In: |
Free radical biology and medicine
Year: 2016, Volume: 101, Pages: 93-101 |
| ISSN: | 1873-4596 |
| DOI: | 10.1016/j.freeradbiomed.2016.10.004 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.freeradbiomed.2016.10.004 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0891584916304464 
|
| Author Notes: | Benjamin Stottmeier, Tobias P. Dick |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698521723 | ||
| 003 | DE-627 | ||
| 005 | 20230427091703.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200519s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.freeradbiomed.2016.10.004 |2 doi | |
| 035 | |a (DE-627)1698521723 | ||
| 035 | |a (DE-599)KXP1698521723 | ||
| 035 | |a (OCoLC)1341325586 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stottmeier, Benjamin |e VerfasserIn |0 (DE-588)1126535389 |0 (DE-627)881022578 |0 (DE-576)484564285 |4 aut | |
| 245 | 1 | 0 | |a Redox sensitivity of the MyD88 immune signaling adapter |c Benjamin Stottmeier, Tobias P. Dick |
| 264 | 1 | |c 05 October 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.05.2020 | ||
| 520 | |a The transcription factor nuclear factor-κB (NF-κB) mediates expression of key genes involved in innate immunity and inflammation. NF-κB activation has been repeatedly reported to be modulated by hydrogen peroxide (H2O2). Here, we show that the NF-κB-activating signaling adapter myeloid differentiation primary response gene 88 (MyD88) is highly sensitive to oxidation by H2O2 and may be redox-regulated in its function, thus facilitating an influence of H2O2 on the NF-κB signaling pathway. Upon oxidation, MyD88 forms distinct disulfide-linked conjugates which are reduced by the MyD88-interacting oxidoreductase nucleoredoxin (Nrx). MyD88 cysteine residues functionally modulate MyD88-dependent NF-κB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling. | ||
| 650 | 4 | |a Hydrogen peroxide | |
| 650 | 4 | |a MyD88 | |
| 650 | 4 | |a NF-κB | |
| 650 | 4 | |a Redox signaling | |
| 650 | 4 | |a Thiol oxidation | |
| 700 | 1 | |a Dick, Tobias P. |e VerfasserIn |0 (DE-588)1142415805 |0 (DE-627)100217807X |0 (DE-576)494813431 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Free radical biology and medicine |d New York, NY [u.a.] : Elsevier, 1987 |g 101(2016), Seite 93-101 |h Online-Ressource |w (DE-627)300898568 |w (DE-600)1483653-1 |w (DE-576)098330233 |x 1873-4596 |7 nnas |a Redox sensitivity of the MyD88 immune signaling adapter |
| 773 | 1 | 8 | |g volume:101 |g year:2016 |g pages:93-101 |g extent:9 |a Redox sensitivity of the MyD88 immune signaling adapter |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.freeradbiomed.2016.10.004 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0891584916304464 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200519 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1142415805 |a Dick, Tobias P. |m 1142415805:Dick, Tobias P. |d 140000 |e 140000PD1142415805 |k 0/140000/ |p 2 |y j | ||
| 998 | |g 1126535389 |a Stottmeier, Benjamin |m 1126535389:Stottmeier, Benjamin |d 910000 |d 912000 |e 910000PS1126535389 |e 912000PS1126535389 |k 0/910000/ |k 1/910000/912000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1698521723 |e 366850086X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"9 S."}],"relHost":[{"language":["eng"],"recId":"300898568","disp":"Redox sensitivity of the MyD88 immune signaling adapterFree radical biology and medicine","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Ungezählte Beil.: Supplement"],"part":{"pages":"93-101","year":"2016","extent":"9","volume":"101","text":"101(2016), Seite 93-101"},"titleAlt":[{"title":"Free radical biology & medicine"}],"pubHistory":["3.1987 -"],"title":[{"title_sort":"Free radical biology and medicine","subtitle":"the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research","title":"Free radical biology and medicine"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1483653-1"],"eki":["300898568"],"issn":["1873-4596"]},"origin":[{"publisher":"Elsevier","dateIssuedKey":"1987","dateIssuedDisp":"1987-","publisherPlace":"New York, NY [u.a.]"}]}],"origin":[{"dateIssuedDisp":"05 October 2016","dateIssuedKey":"2016"}],"id":{"doi":["10.1016/j.freeradbiomed.2016.10.004"],"eki":["1698521723"]},"name":{"displayForm":["Benjamin Stottmeier, Tobias P. Dick"]},"note":["Gesehen am 19.05.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1698521723","language":["eng"],"title":[{"title":"Redox sensitivity of the MyD88 immune signaling adapter","title_sort":"Redox sensitivity of the MyD88 immune signaling adapter"}],"person":[{"family":"Stottmeier","given":"Benjamin","display":"Stottmeier, Benjamin","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Tobias P.","family":"Dick","role":"aut","display":"Dick, Tobias P.","roleDisplay":"VerfasserIn"}]} | ||
| SRT | |a STOTTMEIERREDOXSENSI0520 | ||