Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice
Aims Myocardial infarction (MI) and heart failure (HF) are risk factors for the development of depression, additionally worsening the quality of life and patient outcome. How HF causes depression and how depression promotes HF remain mechanistically unclear, which is at least partly caused by the di...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 April 2019
|
| In: |
ESC heart failure
Year: 2019, Jahrgang: 6, Heft: 4, Pages: 711-722 |
| ISSN: | 2055-5822 |
| DOI: | 10.1002/ehf2.12440 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/ehf2.12440 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12440 
|
| Verfasserangaben: | Bastian Bruns, Thomas Schmitz, Nathalie Diemert, Chrysovalandis Schwale, Stefanie Maria Werhahn, Friederike Weyrauther, Peter Gass, Miriam Annika Vogt, Hugo Katus, Wolfgang Herzog and Johannes Backs, Jobst-Hendrik Schultz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698521820 | ||
| 003 | DE-627 | ||
| 005 | 20220818091455.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200519s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ehf2.12440 |2 doi | |
| 035 | |a (DE-627)1698521820 | ||
| 035 | |a (DE-599)KXP1698521820 | ||
| 035 | |a (OCoLC)1341325587 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bruns, Bastian |e VerfasserIn |0 (DE-588)1126262714 |0 (DE-627)880857129 |0 (DE-576)483364932 |4 aut | |
| 245 | 1 | 0 | |a Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice |c Bastian Bruns, Thomas Schmitz, Nathalie Diemert, Chrysovalandis Schwale, Stefanie Maria Werhahn, Friederike Weyrauther, Peter Gass, Miriam Annika Vogt, Hugo Katus, Wolfgang Herzog and Johannes Backs, Jobst-Hendrik Schultz |
| 264 | 1 | |c 26 April 2019 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online 26 April 2019 | ||
| 500 | |a Gesehen am 19.05.2020 | ||
| 520 | |a Aims Myocardial infarction (MI) and heart failure (HF) are risk factors for the development of depression, additionally worsening the quality of life and patient outcome. How HF causes depression and how depression promotes HF remain mechanistically unclear, which is at least partly caused by the difficulty of in vivo modelling of psychosomatic co-morbidity. We aimed to study the potential sequence of events with respect to different depression aspects upon HF. Methods and results Male C57BL6 mice underwent MI, followed by behavioural and echocardiographic characterization. Motility, exploration, and anxiety-like behaviour were unaffected in mice after MI. We did not observe increased depressive-like behaviour in the sucrose preference, tail suspension, or Porsolt forced swim test. Mice did not display signs of learned helplessness (LH) when compared to sham. Accordingly, cluster analysis revealed only a slightly higher quota of LH in HF (38%) vs. sham mice (32%). But strikingly, three-group cluster analysis revealed an additional intermediate subpopulation at risk for LH after HF (29%). Interestingly, this population featured elevated cardiac expression of nr4a1. Conclusions The LH paradigm uncovered a subtle predisposition to depressive-like behaviour after MI, whereas testing for anhedonia and despair was insufficient to show a behavioural shift in mice. Therefore, we suggest an accumulating risk profile and a multiple-hits hypothesis regarding the pathogenesis of co-morbid depression after MI. Symptoms of LH may present a marker of subclinical depression after MI, the impact of which remains to be investigated. The proposed sequence of behavioural testing enables the mechanistic dissection of cardio-psychogenic signalling in the future. | ||
| 650 | 4 | |a Anxiety | |
| 650 | 4 | |a Co-morbidity | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Learned helplessness | |
| 650 | 4 | |a Myocardial infarction | |
| 700 | 1 | |a Schmitz, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diemert, Nathalie |d 1989- |e VerfasserIn |0 (DE-588)1072793520 |0 (DE-627)828353530 |0 (DE-576)434228052 |4 aut | |
| 700 | 1 | |a Schwale, Chrysovalandis |d 1984- |e VerfasserIn |0 (DE-588)1063009650 |0 (DE-627)807120006 |0 (DE-576)420366938 |4 aut | |
| 700 | 1 | |a Werhahn, Stefanie |d 1989- |e VerfasserIn |0 (DE-588)1183971486 |0 (DE-627)1663447241 |4 aut | |
| 700 | 1 | |a Weyrauther, Friederike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gass, Peter |d 1963- |e VerfasserIn |0 (DE-588)13015945X |0 (DE-627)492009694 |0 (DE-576)298033771 |4 aut | |
| 700 | 1 | |a Vogt, Miriam A. |e VerfasserIn |0 (DE-588)143035800 |0 (DE-627)704370875 |0 (DE-576)334702607 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Herzog, Wolfgang |d 1953- |e VerfasserIn |0 (DE-588)1028064535 |0 (DE-627)730257452 |0 (DE-576)375551816 |4 aut | |
| 700 | 1 | |a Backs, Johannes |d 1971- |e VerfasserIn |0 (DE-588)123819040 |0 (DE-627)706437462 |0 (DE-576)293892946 |4 aut | |
| 700 | 1 | |a Schultz, Jobst-Hendrik |e VerfasserIn |0 (DE-588)1033481696 |0 (DE-627)741303361 |0 (DE-576)170664899 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Society of Cardiology |t ESC heart failure |d Chichester : Wiley, 2014 |g 6(2019), 4, Seite 711-722 |h Online-Ressource |w (DE-627)820686506 |w (DE-600)2814355-3 |w (DE-576)427947944 |x 2055-5822 |7 nnas |
| 773 | 1 | 8 | |g volume:6 |g year:2019 |g number:4 |g pages:711-722 |g extent:12 |a Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ehf2.12440 |x Verlag |x Resolving-System |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12440 |x Verlag |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20200519 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1033481696 |a Schultz, Jobst-Hendrik |m 1033481696:Schultz, Jobst-Hendrik |d 910000 |d 910100 |d 50000 |e 910000PS1033481696 |e 910100PS1033481696 |e 50000PS1033481696 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 12 |y j | ||
| 998 | |g 123819040 |a Backs, Johannes |m 123819040:Backs, Johannes |d 910000 |d 910100 |e 910000PB123819040 |e 910100PB123819040 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1028064535 |a Herzog, Wolfgang |m 1028064535:Herzog, Wolfgang |d 910000 |d 910100 |e 910000PH1028064535 |e 910100PH1028064535 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 143035800 |a Vogt, Miriam A. |m 143035800:Vogt, Miriam A. |d 700000 |d 710000 |e 700000PV143035800 |e 710000PV143035800 |k 0/700000/ |k 1/700000/710000/ |p 8 | ||
| 998 | |g 13015945X |a Gass, Peter |m 13015945X:Gass, Peter |d 60000 |e 60000PG13015945X |k 0/60000/ |p 7 | ||
| 998 | |g 1183971486 |a Werhahn, Stefanie |m 1183971486:Werhahn, Stefanie |d 910000 |d 910100 |e 910000PW1183971486 |e 910100PW1183971486 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1063009650 |a Schwale, Chrysovalandis |m 1063009650:Schwale, Chrysovalandis |d 50000 |d 53200 |e 50000PS1063009650 |e 53200PS1063009650 |k 0/50000/ |k 1/50000/53200/ |p 4 | ||
| 998 | |g 1072793520 |a Diemert, Nathalie |m 1072793520:Diemert, Nathalie |d 910000 |d 910100 |e 910000PD1072793520 |e 910100PD1072793520 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1126262714 |a Bruns, Bastian |m 1126262714:Bruns, Bastian |d 910000 |d 910100 |e 910000PB1126262714 |e 910100PB1126262714 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1698521820 |e 3668501181 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"820686506","origin":[{"publisher":"Wiley","dateIssuedDisp":"2014-","dateIssuedKey":"2014","publisherPlace":"Chichester"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2814355-3"],"eki":["820686506"],"issn":["2055-5822"]},"title":[{"title":"ESC heart failure","title_sort":"ESC heart failure"}],"note":["Gesehen am 29.05.2020"],"pubHistory":["1.2014 -"],"part":{"year":"2019","volume":"6","text":"6(2019), 4, Seite 711-722","issue":"4","extent":"12","pages":"711-722"},"language":["eng"],"corporate":[{"role":"aut","display":"European Society of Cardiology"}],"disp":"European Society of CardiologyESC heart failure","type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"26 April 2019"}],"title":[{"title":"Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice","title_sort":"Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1002/ehf2.12440"],"eki":["1698521820"]},"physDesc":[{"extent":"12 S."}],"recId":"1698521820","person":[{"role":"aut","family":"Bruns","given":"Bastian","display":"Bruns, Bastian"},{"display":"Schmitz, Thomas","given":"Thomas","family":"Schmitz","role":"aut"},{"role":"aut","family":"Diemert","given":"Nathalie","display":"Diemert, Nathalie"},{"display":"Schwale, Chrysovalandis","given":"Chrysovalandis","role":"aut","family":"Schwale"},{"display":"Werhahn, Stefanie","given":"Stefanie","role":"aut","family":"Werhahn"},{"given":"Friederike","display":"Weyrauther, Friederike","family":"Weyrauther","role":"aut"},{"given":"Peter","display":"Gass, Peter","role":"aut","family":"Gass"},{"family":"Vogt","role":"aut","display":"Vogt, Miriam A.","given":"Miriam A."},{"display":"Katus, Hugo","given":"Hugo","role":"aut","family":"Katus"},{"display":"Herzog, Wolfgang","given":"Wolfgang","family":"Herzog","role":"aut"},{"display":"Backs, Johannes","given":"Johannes","role":"aut","family":"Backs"},{"role":"aut","family":"Schultz","given":"Jobst-Hendrik","display":"Schultz, Jobst-Hendrik"}],"note":["Published online 26 April 2019","Gesehen am 19.05.2020"],"language":["eng"],"name":{"displayForm":["Bastian Bruns, Thomas Schmitz, Nathalie Diemert, Chrysovalandis Schwale, Stefanie Maria Werhahn, Friederike Weyrauther, Peter Gass, Miriam Annika Vogt, Hugo Katus, Wolfgang Herzog and Johannes Backs, Jobst-Hendrik Schultz"]}} | ||
| SRT | |a BRUNSBASTILEARNEDHEL2620 | ||