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Stemness genes expression in naive vs. osteodifferentiated human dental-derived stem cells

OBJECTIVE: Mesenchymal stem cells (MSCs) have been deeply investigated in regenerative medicine because of their crucial role in tissue healing, such as tissue regeneration. Dental-derived stem cells (d-DSCs) are easily available from dental tissues, which can be isolated from all age patients with...

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Main Authors: Ballini, Andrea (Author) , Di Benedetto, A. (Author) , De Vito, D. (Author) , Scarano, A. (Author) , Scacco, S. (Author) , Perillo, L. (Author) , Posa, Francesca (Author) , Dipalma, G. (Author) , Paduano, F. (Author) , Contaldo, M. (Author) , Grano, M. (Author) , Brunetti, G. (Author) , Colaianni, G. (Author) , Di Cosola, M. (Author) , Cantore, S. (Author) , Mori, G. (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: European review for medical and pharmacological sciences
Year: 2019, Volume: 23, Issue: 7, Pages: 2916-2923
ISSN:2284-0729
DOI:10.26355/eurrev_201904_17570
Online Access:Verlag, Volltext: https://doi.org/10.26355/eurrev_201904_17570
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Author Notes:A. Ballini, A. di Benedetto, D. de Vito, A. Scarano, S. Scacco, L. Perillo, F. Posa, G. Dipalma, F. Paduano, M. Contaldo, M. Grano, G. Brunetti, G. Colaianni, M. di Cosola, S. Cantore, G. Mori

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520 |a OBJECTIVE: Mesenchymal stem cells (MSCs) have been deeply investigated in regenerative medicine because of their crucial role in tissue healing, such as tissue regeneration. Dental-derived stem cells (d-DSCs) are easily available from dental tissues, which can be isolated from all age patients with minimal discomfort. PATIENTS AND METHODS: Normal unerupted third molars tooth buds were collected from adolescents' patients underwent to extractions for orthodontic reasons. The expression of the genes Kruppel-like factor 4 (Klf-4), octamer- binding transcription factor 4 (Oct-4), homeobox transcription factor Nanog (NANOG) was investigated in d-DSCs obtained from dental bud (DBSCs), differentiated toward osteoblastic phenotype and not. RESULTS: Our results showed that DBSCs expressed Oct-4, Nanog, and Klf-4 in undifferentiated conditions and interestingly the expression of such genes increased when the cells were kept in osteogenic medium. CONCLUSIONS: These attractive stemness properties, together with the effortlessly isolation, during common oral and maxillofacial surgical procedures, from undifferentiated tissues such as dental bud, make this kind of d-DSCs a promising tool in regenerative medicine, having the potential for clinical applications, and reinforcing the present challenge to develop new preventive and healing strategies in tissue regeneration. 
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