Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
Until today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may in part be explained by data from preclinical models showing significant activity only at h...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 December 2019
|
| In: |
Clinical epigenetics
Year: 2019, Jahrgang: 11 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-019-0775-1 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-019-0775-1
|
| Verfasserangaben: | Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-Peter Schenk, Juliane L. Buhl, Dennis Riehl, Michael C. Frühwald, Arnulf Pekrun, Claudia Rossig, Regina Wieland, Christian Flotho, Uwe Kordes, Bernd Gruhn, Thorsten Simon, Christin Linderkamp, Felix Sahm, Lenka Taylor, Angelika Freitag, Jürgen Burhenne, Kathrin I. Foerster, Andreas D. Meid, Stefan M. Pfister, Irini Karapanagiotou-Schenkel, and Olaf Witt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698603088 | ||
| 003 | DE-627 | ||
| 005 | 20241224004019.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200520s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13148-019-0775-1 |2 doi | |
| 035 | |a (DE-627)1698603088 | ||
| 035 | |a (DE-599)KXP1698603088 | ||
| 035 | |a (OCoLC)1341325947 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tilburg, Cornelis M. van |e VerfasserIn |0 (DE-588)1144664527 |0 (DE-627)1004962355 |0 (DE-576)495479519 |4 aut | |
| 245 | 1 | 0 | |a Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia |c Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-Peter Schenk, Juliane L. Buhl, Dennis Riehl, Michael C. Frühwald, Arnulf Pekrun, Claudia Rossig, Regina Wieland, Christian Flotho, Uwe Kordes, Bernd Gruhn, Thorsten Simon, Christin Linderkamp, Felix Sahm, Lenka Taylor, Angelika Freitag, Jürgen Burhenne, Kathrin I. Foerster, Andreas D. Meid, Stefan M. Pfister, Irini Karapanagiotou-Schenkel, and Olaf Witt |
| 264 | 1 | |c 10 December 2019 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.05.2020 | ||
| 520 | |a Until today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may in part be explained by data from preclinical models showing significant activity only at higher concentrations compared to those achieved with current dosing regimens. In the current pediatric trial, we applied an intra-patient dose escalation design. | ||
| 700 | 1 | |a Milde, Till |d 1973- |e VerfasserIn |0 (DE-588)1038311837 |0 (DE-627)75711234X |0 (DE-576)39229334X |4 aut | |
| 700 | 1 | |a Witt, Ruth |e VerfasserIn |0 (DE-588)115142076X |0 (DE-627)1011646536 |0 (DE-576)497741776 |4 aut | |
| 700 | 1 | |a Ecker, Jonas |d 1988- |e VerfasserIn |0 (DE-588)109722810X |0 (DE-627)857006886 |0 (DE-576)468135251 |4 aut | |
| 700 | 1 | |a Hielscher, Thomas |e VerfasserIn |0 (DE-588)1159594791 |0 (DE-627)1022977768 |0 (DE-576)50506068X |4 aut | |
| 700 | 1 | |a Seitz, Angelika |e VerfasserIn |0 (DE-588)1106414179 |0 (DE-627)863139701 |0 (DE-576)474107019 |4 aut | |
| 700 | 1 | |a Schenk, Jens-Peter |e VerfasserIn |0 (DE-588)1055855114 |0 (DE-627)792738667 |0 (DE-576)260795577 |4 aut | |
| 700 | 1 | |a Buhl, Juliane |d 1988- |e VerfasserIn |0 (DE-588)1162236418 |0 (DE-627)1025708687 |0 (DE-576)507290151 |4 aut | |
| 700 | 1 | |a Riehl, Dennis |d 1987- |e VerfasserIn |0 (DE-588)1130181839 |0 (DE-627)884537102 |0 (DE-576)486638960 |4 aut | |
| 700 | 1 | |a Frühwald, Michael |d 1966- |e VerfasserIn |0 (DE-588)1206269812 |0 (DE-627)1692264028 |4 aut | |
| 700 | 1 | |a Pekrun, Arnulf |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Rössig, Claudia |e VerfasserIn |0 (DE-588)1219583243 |0 (DE-627)1735501670 |4 aut | |
| 700 | 1 | |a Wieland, Regina Paula Franziska |d 1963- |e VerfasserIn |0 (DE-588)17287579X |0 (DE-627)697804569 |0 (DE-576)133731065 |4 aut | |
| 700 | 1 | |a Flotho, Christian |e VerfasserIn |0 (DE-588)118125273 |0 (DE-627)621547123 |0 (DE-576)320525341 |4 aut | |
| 700 | 1 | |a Kordes, Uwe |e VerfasserIn |0 (DE-588)1027412181 |0 (DE-627)729111598 |0 (DE-576)373197896 |4 aut | |
| 700 | 1 | |a Gruhn, Bernd |d 1961- |e VerfasserIn |0 (DE-588)11259901X |0 (DE-627)691154171 |0 (DE-576)289736552 |4 aut | |
| 700 | 1 | |a Simon, Thorsten |d 1971- |e VerfasserIn |0 (DE-588)12090392X |0 (DE-627)080959369 |0 (DE-576)292440081 |4 aut | |
| 700 | 1 | |a Linderkamp, Christin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sahm, Felix |d 1984- |e VerfasserIn |0 (DE-588)1022852132 |0 (DE-627)717318478 |0 (DE-576)366075020 |4 aut | |
| 700 | 1 | |a Taylor, Lenka A. |e VerfasserIn |0 (DE-588)138997853 |0 (DE-627)70317570X |0 (DE-576)30938821X |4 aut | |
| 700 | 1 | |a Freitag, Angelika |e VerfasserIn |0 (DE-588)1151580295 |0 (DE-627)1011924056 |0 (DE-576)497884690 |4 aut | |
| 700 | 1 | |a Burhenne, Jürgen |d 1963- |e VerfasserIn |0 (DE-588)1034228889 |0 (DE-627)745126987 |0 (DE-576)381858197 |4 aut | |
| 700 | 1 | |a Foerster, Kathrin |e VerfasserIn |0 (DE-588)118114602X |0 (DE-627)1662507089 |4 aut | |
| 700 | 1 | |a Meid, Andreas |d 1981- |e VerfasserIn |0 (DE-588)1076301991 |0 (DE-627)834660377 |0 (DE-576)445184582 |4 aut | |
| 700 | 1 | |a Pfister, Stefan |d 1974- |e VerfasserIn |0 (DE-588)123850215 |0 (DE-627)706450930 |0 (DE-576)293908400 |4 aut | |
| 700 | 1 | |a Karapanagiotou-Schenkel, Irini |e VerfasserIn |0 (DE-588)1101472952 |0 (DE-627)859729141 |0 (DE-576)469905905 |4 aut | |
| 700 | 1 | |a Witt, Olaf |d 1965- |e VerfasserIn |0 (DE-588)17275030X |0 (DE-627)697681750 |0 (DE-576)133607410 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical epigenetics |d [Erscheinungsort nicht ermittelbar] : BioMed Central, 2010 |g 11(2019) Artikel-Nummer 188, 15 Seiten |h Online-Ressource |w (DE-627)626459028 |w (DE-600)2553921-8 |w (DE-576)325002916 |x 1868-7083 |7 nnas |a Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g extent:15 |a Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13148-019-0775-1 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20200520 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 17275030X |a Witt, Olaf |m 17275030X:Witt, Olaf |d 910000 |d 910500 |e 910000PW17275030X |e 910500PW17275030X |k 0/910000/ |k 1/910000/910500/ |p 27 |y j | ||
| 998 | |g 123850215 |a Pfister, Stefan |m 123850215:Pfister, Stefan |d 910000 |d 910500 |e 910000PP123850215 |e 910500PP123850215 |k 0/910000/ |k 1/910000/910500/ |p 25 | ||
| 998 | |g 1076301991 |a Meid, Andreas |m 1076301991:Meid, Andreas |d 910000 |d 910100 |e 910000PM1076301991 |e 910100PM1076301991 |k 0/910000/ |k 1/910000/910100/ |p 24 | ||
| 998 | |g 118114602X |a Foerster, Kathrin |m 118114602X:Foerster, Kathrin |d 910000 |d 910100 |e 910000PF118114602X |e 910100PF118114602X |k 0/910000/ |k 1/910000/910100/ |p 23 | ||
| 998 | |g 1034228889 |a Burhenne, Jürgen |m 1034228889:Burhenne, Jürgen |d 910000 |d 910100 |e 910000PB1034228889 |e 910100PB1034228889 |k 0/910000/ |k 1/910000/910100/ |p 22 | ||
| 998 | |g 138997853 |a Taylor, Lenka A. |m 138997853:Taylor, Lenka A. |d 160000 |d 160100 |e 160000PT138997853 |e 160100PT138997853 |k 0/160000/ |k 1/160000/160100/ |p 20 | ||
| 998 | |g 1022852132 |a Sahm, Felix |m 1022852132:Sahm, Felix |d 910000 |d 912000 |e 910000PS1022852132 |e 912000PS1022852132 |k 0/910000/ |k 1/910000/912000/ |p 19 | ||
| 998 | |g 1162236418 |a Buhl, Juliane |m 1162236418:Buhl, Juliane |d 140000 |e 140000PB1162236418 |k 0/140000/ |p 8 | ||
| 998 | |g 1055855114 |a Schenk, Jens-Peter |m 1055855114:Schenk, Jens-Peter |d 910000 |d 911400 |e 910000PS1055855114 |e 911400PS1055855114 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 1106414179 |a Seitz, Angelika |m 1106414179:Seitz, Angelika |d 910000 |d 911100 |e 910000PS1106414179 |e 911100PS1106414179 |k 0/910000/ |k 1/910000/911100/ |p 6 | ||
| 998 | |g 1159594791 |a Hielscher, Thomas |m 1159594791:Hielscher, Thomas |d 140000 |e 140000PH1159594791 |k 0/140000/ |p 5 | ||
| 998 | |g 109722810X |a Ecker, Jonas |m 109722810X:Ecker, Jonas |d 910000 |d 910500 |e 910000PE109722810X |e 910500PE109722810X |k 0/910000/ |k 1/910000/910500/ |p 4 | ||
| 998 | |g 115142076X |a Witt, Ruth |m 115142076X:Witt, Ruth |d 910000 |d 910500 |e 910000PW115142076X |e 910500PW115142076X |k 0/910000/ |k 1/910000/910500/ |p 3 | ||
| 998 | |g 1038311837 |a Milde, Till |m 1038311837:Milde, Till |d 910000 |d 910500 |e 910000PM1038311837 |e 910500PM1038311837 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 998 | |g 1144664527 |a Tilburg, Cornelis M. van |m 1144664527:Tilburg, Cornelis M. van |d 910000 |d 910500 |e 910000PT1144664527 |e 910500PT1144664527 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1698603088 |e 3668759294 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-Peter Schenk, Juliane L. Buhl, Dennis Riehl, Michael C. Frühwald, Arnulf Pekrun, Claudia Rossig, Regina Wieland, Christian Flotho, Uwe Kordes, Bernd Gruhn, Thorsten Simon, Christin Linderkamp, Felix Sahm, Lenka Taylor, Angelika Freitag, Jürgen Burhenne, Kathrin I. Foerster, Andreas D. Meid, Stefan M. Pfister, Irini Karapanagiotou-Schenkel, and Olaf Witt"]},"id":{"eki":["1698603088"],"doi":["10.1186/s13148-019-0775-1"]},"person":[{"display":"Tilburg, Cornelis M. van","given":"Cornelis M. van","role":"aut","family":"Tilburg"},{"display":"Milde, Till","role":"aut","given":"Till","family":"Milde"},{"family":"Witt","given":"Ruth","role":"aut","display":"Witt, Ruth"},{"role":"aut","given":"Jonas","family":"Ecker","display":"Ecker, Jonas"},{"role":"aut","given":"Thomas","family":"Hielscher","display":"Hielscher, Thomas"},{"family":"Seitz","role":"aut","given":"Angelika","display":"Seitz, Angelika"},{"display":"Schenk, Jens-Peter","role":"aut","given":"Jens-Peter","family":"Schenk"},{"role":"aut","given":"Juliane","family":"Buhl","display":"Buhl, Juliane"},{"display":"Riehl, Dennis","family":"Riehl","given":"Dennis","role":"aut"},{"family":"Frühwald","role":"aut","given":"Michael","display":"Frühwald, Michael"},{"family":"Pekrun","role":"aut","given":"Arnulf","display":"Pekrun, Arnulf"},{"display":"Rössig, Claudia","family":"Rössig","given":"Claudia","role":"aut"},{"display":"Wieland, Regina Paula Franziska","given":"Regina Paula Franziska","role":"aut","family":"Wieland"},{"role":"aut","given":"Christian","family":"Flotho","display":"Flotho, Christian"},{"role":"aut","given":"Uwe","family":"Kordes","display":"Kordes, Uwe"},{"given":"Bernd","role":"aut","family":"Gruhn","display":"Gruhn, Bernd"},{"display":"Simon, Thorsten","family":"Simon","given":"Thorsten","role":"aut"},{"family":"Linderkamp","role":"aut","given":"Christin","display":"Linderkamp, Christin"},{"role":"aut","given":"Felix","family":"Sahm","display":"Sahm, Felix"},{"display":"Taylor, Lenka A.","given":"Lenka A.","role":"aut","family":"Taylor"},{"family":"Freitag","given":"Angelika","role":"aut","display":"Freitag, Angelika"},{"role":"aut","given":"Jürgen","family":"Burhenne","display":"Burhenne, Jürgen"},{"family":"Foerster","given":"Kathrin","role":"aut","display":"Foerster, Kathrin"},{"family":"Meid","given":"Andreas","role":"aut","display":"Meid, Andreas"},{"display":"Pfister, Stefan","family":"Pfister","role":"aut","given":"Stefan"},{"given":"Irini","role":"aut","family":"Karapanagiotou-Schenkel","display":"Karapanagiotou-Schenkel, Irini"},{"given":"Olaf","role":"aut","family":"Witt","display":"Witt, Olaf"}],"relHost":[{"id":{"eki":["626459028"],"issn":["1868-7083"],"zdb":["2553921-8"]},"title":[{"title":"Clinical epigenetics","title_sort":"Clinical epigenetics"}],"part":{"text":"11(2019) Artikel-Nummer 188, 15 Seiten","volume":"11","extent":"15","year":"2019"},"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 27.05.2020"],"origin":[{"publisher":"BioMed Central ; Springer","dateIssuedKey":"2010","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; Berlin ; Heidelberg [u.a.]","dateIssuedDisp":"2010-"}],"pubHistory":["1.2010 -"],"disp":"Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemiaClinical epigenetics","recId":"626459028","physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"10 December 2019","dateIssuedKey":"2019"}],"title":[{"title_sort":"Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia","title":"Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia"}],"note":["Gesehen am 20.05.2020"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1698603088","physDesc":[{"extent":"15 S."}]} | ||
| SRT | |a TILBURGCORPHASEIIIIN1020 | ||