Stimulation of central α2 receptors attenuates experimental necrotizing pancreatitis
Severe necrotizing pancreatitis (SNP) is a disease with relevant morbidity and mortality until today. No specific therapy is in sight. Central α2 agonists such as clonidine and dexmedetomidine are known to have anti-inflammatory effects though the cholinergic anti-inflammatory pathway and are implem...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2016
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| In: |
Pancreas
Year: 2016, Volume: 45, Issue: 2, Pages: 260-264 |
| ISSN: | 1536-4828 |
| DOI: | 10.1097/MPA.0000000000000474 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000000474 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Fulltext/2016/02000/Stimulation_of_Central__2_Receptors_Attenuates.15.aspx 
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| Author Notes: | Lutz Schneider, Bahar Jabrailova, Mohammed Salem, Karl Kilk, Stefan Hofer, Thorsten Brenner, Oliver Strobel, Thilo Hackert, and Jens Werner |
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| 520 | |a Severe necrotizing pancreatitis (SNP) is a disease with relevant morbidity and mortality until today. No specific therapy is in sight. Central α2 agonists such as clonidine and dexmedetomidine are known to have anti-inflammatory effects though the cholinergic anti-inflammatory pathway and are implemented in the clinical routine as adjunct sedative drugs. Their potential effect on SNP has not yet been tested. | ||
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