De novo neurogenesis by targeted expression of atoh7 to Müller glia cells
Skip to Next Section - Regenerative responses in the vertebrate CNS depend on quiescent radial glia stem cells, which re-enter the cell cycle and eventually differentiate into neurons. The entry into the cell cycle and the differentiation into neurons are events of opposite nature, and therefore eff...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 June 2016
|
| In: |
Development
Year: 2016, Jahrgang: 143, Heft: 11, Pages: 1874-1883 |
| ISSN: | 1477-9129 |
| DOI: | 10.1242/dev.135905 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/dev.135905 Verlag, lizenzpflichtig, Volltext: https://dev.biologists.org/content/143/11/1874 
|
| Verfasserangaben: | Katharina Lust, Rebecca Sinn, Alicia Pérez Saturnino, Lázaro Centanin and Joachim Wittbrodt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698619545 | ||
| 003 | DE-627 | ||
| 005 | 20220818093024.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200520s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1242/dev.135905 |2 doi | |
| 035 | |a (DE-627)1698619545 | ||
| 035 | |a (DE-599)KXP1698619545 | ||
| 035 | |a (OCoLC)1341325810 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Lust, Katharina |e VerfasserIn |0 (DE-588)1124412263 |0 (DE-627)878087400 |0 (DE-576)482493526 |4 aut | |
| 245 | 1 | 0 | |a De novo neurogenesis by targeted expression of atoh7 to Müller glia cells |c Katharina Lust, Rebecca Sinn, Alicia Pérez Saturnino, Lázaro Centanin and Joachim Wittbrodt |
| 264 | 1 | |c 1 June 2016 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.05.2020 | ||
| 520 | |a Skip to Next Section - Regenerative responses in the vertebrate CNS depend on quiescent radial glia stem cells, which re-enter the cell cycle and eventually differentiate into neurons. The entry into the cell cycle and the differentiation into neurons are events of opposite nature, and therefore efforts to force quiescent radial glia into neurons require different factors. Here, we use fish to show that a single neurogenic factor, Atoh7, directs retinal radial glia (Müller glia, MG) into proliferation. The resulting neurogenic clusters differentiate in vivo into various retinal neurons. We use signaling reporters to demonstrate that the Atoh7-induced regeneration-like response of MG cells is mimicked by Notch, resembling the behavior of early progenitors during retinogenesis. Activation of Notch signaling in MG cells is sufficient to trigger proliferation and differentiation. Our results uncover a new role for Atoh7 as a universal neurogenic factor, and illustrate how signaling modules are re-employed in diverse contexts to trigger different biological responses. | ||
| 700 | 1 | |a Sinn, Rebecca |e VerfasserIn |0 (DE-588)105005170X |0 (DE-627)783249802 |0 (DE-576)404349919 |4 aut | |
| 700 | 1 | |a Pérez Saturnino, Alicia |e VerfasserIn |0 (DE-588)1173807217 |0 (DE-627)1043630503 |0 (DE-576)515710555 |4 aut | |
| 700 | 1 | |a Centanin, Lázaro |e VerfasserIn |0 (DE-588)105927664X |0 (DE-627)798228431 |0 (DE-576)415156548 |4 aut | |
| 700 | 1 | |a Wittbrodt, Joachim |e VerfasserIn |0 (DE-588)1038250919 |0 (DE-627)756835356 |0 (DE-576)167753401 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Development |d Cambridge : The Company of Biologists, 1987 |g 143(2016), 11, Seite 1874-1883 |h Online-Ressource |w (DE-627)31982439X |w (DE-600)2007916-3 |w (DE-576)090893131 |x 1477-9129 |7 nnas |a De novo neurogenesis by targeted expression of atoh7 to Müller glia cells |
| 773 | 1 | 8 | |g volume:143 |g year:2016 |g number:11 |g pages:1874-1883 |g extent:10 |a De novo neurogenesis by targeted expression of atoh7 to Müller glia cells |
| 856 | 4 | 0 | |u https://doi.org/10.1242/dev.135905 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://dev.biologists.org/content/143/11/1874 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200520 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1038250919 |a Wittbrodt, Joachim |m 1038250919:Wittbrodt, Joachim |d 700000 |d 721000 |e 700000PW1038250919 |e 721000PW1038250919 |k 0/700000/ |k 1/700000/721000/ |p 5 |y j | ||
| 998 | |g 105927664X |a Centanin, Lázaro |m 105927664X:Centanin, Lázaro |d 700000 |d 721000 |e 700000PC105927664X |e 721000PC105927664X |k 0/700000/ |k 1/700000/721000/ |p 4 | ||
| 998 | |g 1173807217 |a Pérez Saturnino, Alicia |m 1173807217:Pérez Saturnino, Alicia |d 700000 |d 721000 |e 700000PP1173807217 |e 721000PP1173807217 |k 0/700000/ |k 1/700000/721000/ |p 3 | ||
| 998 | |g 105005170X |a Sinn, Rebecca |m 105005170X:Sinn, Rebecca |p 2 | ||
| 998 | |g 1124412263 |a Lust, Katharina |m 1124412263:Lust, Katharina |d 700000 |d 721000 |e 700000PL1124412263 |e 721000PL1124412263 |k 0/700000/ |k 1/700000/721000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1698619545 |e 3668792704 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Katharina Lust, Rebecca Sinn, Alicia Pérez Saturnino, Lázaro Centanin and Joachim Wittbrodt"]},"id":{"eki":["1698619545"],"doi":["10.1242/dev.135905"]},"recId":"1698619545","physDesc":[{"extent":"10 S."}],"origin":[{"dateIssuedDisp":"1 June 2016","dateIssuedKey":"2016"}],"relHost":[{"id":{"zdb":["2007916-3"],"eki":["31982439X"],"issn":["1477-9129"]},"part":{"pages":"1874-1883","extent":"10","text":"143(2016), 11, Seite 1874-1883","issue":"11","year":"2016","volume":"143"},"name":{"displayForm":["Company of Biologists"]},"titleAlt":[{"title":"Development <Cambridge>"}],"pubHistory":["Volume 99, 1 (January 1987)-"],"corporate":[{"display":"The Company of Biologists","role":"isb"}],"title":[{"title":"Development","title_sort":"Development"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 26.06.2025"],"origin":[{"publisher":"The Company of Biologists","dateIssuedKey":"1987","publisherPlace":"Cambridge","dateIssuedDisp":"1987-"}],"disp":"De novo neurogenesis by targeted expression of atoh7 to Müller glia cellsDevelopment","recId":"31982439X","physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","given":"Katharina","family":"Lust","display":"Lust, Katharina"},{"family":"Sinn","given":"Rebecca","role":"aut","display":"Sinn, Rebecca"},{"family":"Pérez Saturnino","role":"aut","given":"Alicia","display":"Pérez Saturnino, Alicia"},{"given":"Lázaro","role":"aut","family":"Centanin","display":"Centanin, Lázaro"},{"display":"Wittbrodt, Joachim","family":"Wittbrodt","role":"aut","given":"Joachim"}],"title":[{"title":"De novo neurogenesis by targeted expression of atoh7 to Müller glia cells","title_sort":"De novo neurogenesis by targeted expression of atoh7 to Müller glia cells"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 20.05.2020"]} | ||
| SRT | |a LUSTKATHARDENOVONEUR1201 | ||