Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2016
|
| In: |
Nature structural & molecular biology
Year: 2016, Jahrgang: 23, Heft: 2, Pages: 116-124 |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.3151 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.3151 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.3151 
|
| Verfasserangaben: | Lars Schomacher, Dandan Han, Michael U. Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698660057 | ||
| 003 | DE-627 | ||
| 005 | 20220818094146.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200520s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/nsmb.3151 |2 doi | |
| 035 | |a (DE-627)1698660057 | ||
| 035 | |a (DE-599)KXP1698660057 | ||
| 035 | |a (OCoLC)1341326183 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Schomacher, Lars |d 1977- |e VerfasserIn |0 (DE-588)136150446 |0 (DE-627)577194682 |0 (DE-576)300861443 |4 aut | |
| 245 | 1 | 0 | |a Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation |c Lars Schomacher, Dandan Han, Michael U. Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs |
| 264 | 1 | |c 11 January 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Das PDF enthält zusätzlich einen Anhang von drei Seiten | ||
| 500 | |a Gesehen am 20.05.2020 | ||
| 520 | |a During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair. | ||
| 700 | 1 | |a Han, Dandan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Musheev, Michael U. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arab, Khelifa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kienhöfer, Sabine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seggern, Annika von |e VerfasserIn |4 aut | |
| 700 | 1 | |a Niehrs, Christof |d 1962- |e VerfasserIn |0 (DE-588)112676324 |0 (DE-627)729343014 |0 (DE-576)373331754 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature structural & molecular biology |d London [u.a.] : Nature Publishing Group, 2004 |g 23(2016), 2, Seite 116-124 |h Online-Ressource |w (DE-627)37683126X |w (DE-600)2131437-8 |w (DE-576)109293967 |x 1545-9985 |7 nnas |a Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation |
| 773 | 1 | 8 | |g volume:23 |g year:2016 |g number:2 |g pages:116-124 |g extent:9 |a Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation |
| 856 | 4 | 0 | |u https://doi.org/10.1038/nsmb.3151 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/nsmb.3151 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200520 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 112676324 |a Niehrs, Christof |m 112676324:Niehrs, Christof |p 7 |y j | ||
| 999 | |a KXP-PPN1698660057 |e 366894914X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Lars Schomacher, Dandan Han, Michael U. Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs"]},"title":[{"title_sort":"Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation","title":"Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation"}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["11.2004 -"],"disp":"Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylationNature structural & molecular biology","title":[{"title":"Nature structural & molecular biology","title_sort":"Nature structural & molecular biology"}],"id":{"zdb":["2131437-8"],"eki":["37683126X"],"issn":["1545-9985"]},"part":{"issue":"2","text":"23(2016), 2, Seite 116-124","pages":"116-124","volume":"23","extent":"9","year":"2016"},"origin":[{"dateIssuedDisp":"2004-","dateIssuedKey":"2004","publisher":"Nature Publishing Group","publisherPlace":"London [u.a.]"}],"note":["Gesehen am 01.03.05"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"37683126X"}],"origin":[{"dateIssuedDisp":"11 January 2016","dateIssuedKey":"2016"}],"id":{"doi":["10.1038/nsmb.3151"],"eki":["1698660057"]},"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Schomacher, Lars","given":"Lars","family":"Schomacher"},{"given":"Dandan","family":"Han","display":"Han, Dandan","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Musheev, Michael U.","given":"Michael U.","family":"Musheev"},{"display":"Arab, Khelifa","roleDisplay":"VerfasserIn","role":"aut","given":"Khelifa","family":"Arab"},{"family":"Kienhöfer","given":"Sabine","display":"Kienhöfer, Sabine","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Annika von","family":"Seggern","role":"aut","roleDisplay":"VerfasserIn","display":"Seggern, Annika von"},{"given":"Christof","family":"Niehrs","display":"Niehrs, Christof","role":"aut","roleDisplay":"VerfasserIn"}],"note":["Das PDF enthält zusätzlich einen Anhang von drei Seiten","Gesehen am 20.05.2020"],"language":["eng"],"recId":"1698660057","physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a SCHOMACHERNEILDNAGLY1120 | ||