KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons
Synaptic inhibition in the spinal cord is mediated mainly by strychnine-sensitive glycine (GlyRs) and by γ-aminobutyric acid type A receptors (GABAAR). During neuronal maturation, neonatal GlyRs containing α2 subunits are replaced by adult-type GlyRs harboring α1 and α3 subunits. At the same time pe...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 January 2016
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| In: |
Histochemistry and cell biology
Year: 2016, Volume: 145, Issue: 6, Pages: 637-646 |
| ISSN: | 1432-119X |
| DOI: | 10.1007/s00418-015-1397-0 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00418-015-1397-0 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007%2Fs00418-015-1397-0 
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| Author Notes: | Chrysovalandis Schwale, Stefanie Schumacher, Claus Bruehl, Stefan Titz, Andrea Schlicksupp, Mirka Kokocinska, Joachim Kirsch, Andreas Draguhn, Jochen Kuhse |
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| 520 | |a Synaptic inhibition in the spinal cord is mediated mainly by strychnine-sensitive glycine (GlyRs) and by γ-aminobutyric acid type A receptors (GABAAR). During neuronal maturation, neonatal GlyRs containing α2 subunits are replaced by adult-type GlyRs harboring α1 and α3 subunits. At the same time period of postnatal development, the transmembrane chloride gradient is changed due to increased expression of the potassium-chloride cotransporter (KCC2), thereby shifting the GABA- and glycine-mediated synaptic currents from mostly excitatory depolarization to inhibitory hyperpolarization. Here, we used RNA interference to suppress KCC2 expression during in vitro maturation of spinal cord neurons. | ||
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