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Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory retrieval. Here we combine cell-type...

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Main Authors: Madroñal, Noelia (Author) , Delgado-García, José M. (Author) , Fernández-Guizán, Azahara (Author) , Chatterjee, Jayanta (Author) , Köhn, Maja (Author) , Mattucci, Camilla (Author) , Jain, Apar (Author) , Tsetsenis, Theodoros (Author) , Illarionova, Anna (Author) , Grinevich, Valéry (Author) , Gross, Cornelius T. (Author) , Gruart, Agnès (Author)
Format: Article (Journal)
Language:English
Published: 18 Mar 2016
In: Nature Communications
Year: 2016, Volume: 7
ISSN:2041-1723
DOI:10.1038/ncomms10923
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms10923
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms10923
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Author Notes:Noelia Madroñal, José M. Delgado-García, Azahara Fernández-Guizán, Jayanta Chatterjee, Maja Köhn, Camilla Mattucci, Apar Jain, Theodoros Tsetsenis, Anna Illarionova, Valery Grinevich, Cornelius T. Gross & Agnès Gruart
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Summary:The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory retrieval. Here we combine cell-type specific neural inhibition with electrophysiological measurements of learning-associated plasticity in behaving mice to demonstrate that dentate gyrus granule cells are not required for memory retrieval, but instead have an unexpected role in memory maintenance. Furthermore, we demonstrate the translational potential of our findings by showing that pharmacological activation of an endogenous inhibitory receptor expressed selectively in dentate gyrus granule cells can induce a rapid loss of hippocampal memory. These findings open a new avenue for the targeted erasure of episodic and contextual memories.
Item Description:Gesehen am 26.05.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms10923

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