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Regulation of a spindle positioning factor at kinetochores by SUMO-targeted ubiquitin ligases

Correct function of the mitotic spindle requires balanced interplay of kinetochore and astral microtubules that mediate chromosome segregation and spindle positioning, respectively. Errors therein can cause severe defects ranging from aneuploidy to developmental disorders. Here, we describe a protei...

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Hauptverfasser: Schweiggert, Jörg (VerfasserIn) , Stevermann, Lea (VerfasserIn) , Panigada, Davide (VerfasserIn) , Kammerer, Daniel (VerfasserIn) , Liakopoulos, Dimitris (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 22, 2016
In: Developmental cell
Year: 2016, Jahrgang: 36, Heft: 4, Pages: 415-427
ISSN:1878-1551
DOI:10.1016/j.devcel.2016.01.011
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.devcel.2016.01.011
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1534580716000459
Volltext
Verfasserangaben:Jörg Schweiggert, Lea Stevermann, Davide Panigada, Daniel Kammerer, and Dimitris Liakopoulos
Beschreibung
Zusammenfassung:Correct function of the mitotic spindle requires balanced interplay of kinetochore and astral microtubules that mediate chromosome segregation and spindle positioning, respectively. Errors therein can cause severe defects ranging from aneuploidy to developmental disorders. Here, we describe a protein degradation pathway that functionally links astral microtubules to kinetochores via regulation of a microtubule-associated factor. We show that the yeast spindle positioning protein Kar9 localizes not only to astral but also to kinetochore microtubules, where it becomes targeted for proteasomal degradation by the SUMO-targeted ubiquitin ligases (STUbLs) Slx5-Slx8.
Beschreibung:Gesehen am 27.05.2020
Beschreibung:Online Resource
ISSN:1878-1551
DOI:10.1016/j.devcel.2016.01.011

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