Myc depletion induces a pluripotent dormant state mimicking diapause
Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 11, 2016
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| In: |
Cell
Year: 2016, Jahrgang: 164, Heft: 4, Pages: 668-680 |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2015.12.033 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2015.12.033 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0092867415016979 
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| Verfasserangaben: | Roberta Scognamiglio, Nina Cabezas-Wallscheid, Marc Christian Thier, Sandro Altamura, Alejandro Reyes, Áine M. Prendergast, Daniel Baumgärtner, Larissa S. Carnevalli, Ann Atzberger, Simon Haas, Lisa von Paleske, Thorsten Boroviak, Philipp Wörsdörfer, Marieke A.G. Essers, Ulrich Kloz, Robert N. Eisenman, Frank Edenhofer, Paul Bertone, Wolfgang Huber, Franciscus van der Hoeven, Austin Smith, and Andreas Trumpp |
MARC
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| 520 | |a Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. | ||
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