What is better/reliable, mitosis counting or Ki67/MIB1 staining?
Uncontrolled proliferation is a hallmark of cancers and tumor cell division is a prerequisite for the effectiveness of most conventional anticancer treatments. Thus, by either counting mitotic figures (mitotic index; MI) or immunohistochemical analysis of proliferation associated antigens like Ki-67...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
Oct 13, 2016
|
| In: |
Translational Lung Cancer Research
Year: 2016, Volume: 5, Issue: 5, Pages: 543-546 |
| ISSN: | 2226-4477 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: http://tlcr.amegroups.com/article/view/10020
|
| Author Notes: | Mark Kriegsmann, Arne Warth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1699019320 | ||
| 003 | DE-627 | ||
| 005 | 20220818103137.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200529s2016 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1699019320 | ||
| 035 | |a (DE-599)KXP1699019320 | ||
| 035 | |a (OCoLC)1341326932 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 245 | 1 | 0 | |a What is better/reliable, mitosis counting or Ki67/MIB1 staining? |c Mark Kriegsmann, Arne Warth |
| 264 | 1 | |c Oct 13, 2016 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.05.2020 | ||
| 520 | |a Uncontrolled proliferation is a hallmark of cancers and tumor cell division is a prerequisite for the effectiveness of most conventional anticancer treatments. Thus, by either counting mitotic figures (mitotic index; MI) or immunohistochemical analysis of proliferation associated antigens like Ki-67 (proliferation index; PI), proliferation in cancers was assessed in a multitude of scientific studies. PubMed research for the terms “cancer” AND “proliferation” as well as “lung cancer” AND “proliferation” results in >190,000 and >16,000 hits, respectively. However, despite this exhausting amount of literature the translation of proliferation assessment into daily routine has largely failed. It has its role in some grading systems, e.g., Elston-Ellis grading for breast cancer or the French Federation of Cancer Centers Sarcoma Group (FNCLCC) grading for sarcomas, but has currently no diagnostic meaning for thoracic tumors despite for neuroendocrine tumors, where MI is used to separate typical from atypical carcinoids or large cell neuroendocrine carcinomas. Why was this promising biomarker lost in translation? | ||
| 700 | 1 | |a Warth, Arne |d 1979- |e VerfasserIn |0 (DE-588)132646145 |0 (DE-627)524716927 |0 (DE-576)260019755 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Translational Lung Cancer Research |d [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar], 2012 |g 5(2016), 5, Seite 543-546 |h Online-Ressource |w (DE-627)777778599 |w (DE-600)2754335-3 |w (DE-576)400525224 |x 2226-4477 |7 nnas |a What is better/reliable, mitosis counting or Ki67/MIB1 staining? |
| 773 | 1 | 8 | |g volume:5 |g year:2016 |g number:5 |g pages:543-546 |g extent:4 |a What is better/reliable, mitosis counting or Ki67/MIB1 staining? |
| 856 | 4 | 0 | |u http://tlcr.amegroups.com/article/view/10020 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200529 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 132646145 |a Warth, Arne |m 132646145:Warth, Arne |d 910000 |d 912000 |e 910000PW132646145 |e 912000PW132646145 |k 0/910000/ |k 1/910000/912000/ |p 2 |y j | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 912000 |e 910000PK103740324X |e 912000PK103740324X |k 0/910000/ |k 1/910000/912000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1699019320 |e 3675689018 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 29.05.2020"],"recId":"1699019320","type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"What is better/reliable, mitosis counting or Ki67/MIB1 staining?","title_sort":"What is better/reliable, mitosis counting or Ki67/MIB1 staining?"}],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"Oct 13, 2016"}],"name":{"displayForm":["Mark Kriegsmann, Arne Warth"]},"id":{"eki":["1699019320"]},"physDesc":[{"extent":"4 S."}],"relHost":[{"disp":"What is better/reliable, mitosis counting or Ki67/MIB1 staining?Translational Lung Cancer Research","language":["eng"],"name":{"displayForm":["Society for Translational Cancer Research (STCR)"]},"origin":[{"dateIssuedKey":"2012","publisherPlace":"[Erscheinungsort nicht ermittelbar]","publisher":"[Verlag nicht ermittelbar]","dateIssuedDisp":"2012-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"TLCR","title":"Translational Lung Cancer Research","title_sort":"Translational Lung Cancer Research"}],"id":{"issn":["2226-4477"],"eki":["777778599"],"zdb":["2754335-3"]},"titleAlt":[{"title":"Transl Lung Cancer Res"},{"title":"TLCR"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2012 -"],"note":["Gesehen am 03.12.2021"],"part":{"extent":"4","year":"2016","pages":"543-546","text":"5(2016), 5, Seite 543-546","issue":"5","volume":"5"},"recId":"777778599"}],"person":[{"display":"Kriegsmann, Mark","given":"Mark","roleDisplay":"VerfasserIn","role":"aut","family":"Kriegsmann"},{"family":"Warth","display":"Warth, Arne","roleDisplay":"VerfasserIn","role":"aut","given":"Arne"}],"language":["eng"]} | ||
| SRT | |a KRIEGSMANNWHATISBETT1320 | ||