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Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75

Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this...

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Main Authors: Krumbholz, Markus (Author) , Hofstadt-van Oy, Ulrich (Author) , Angstwurm, Klemens (Author) , Kleiter, Ingo (Author) , Jarius, Sven (Author) , Paul, Friedemann (Author) , Aktas, Orhan (Author) , Buchholz, Grete (Author) , Kern, Peter (Author) , Straube, Andreas (Author) , Kümpfel, Tania (Author)
Format: Article (Journal)
Language:English
Published: 10 May 2015
In: Journal of neurology
Year: 2015, Volume: 262, Issue: 5, Pages: 1379-1384
ISSN:1432-1459
DOI:10.1007/s00415-015-7766-8
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00415-015-7766-8
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007%2Fs00415-015-7766-8
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Author Notes:Markus Krumbholz, Ulrich Hofstadt-van Oy, Klemens Angstwurm, Ingo Kleiter, Sven Jarius, Friedemann Paul, Orhan Aktas, Grete Buchholz, Peter Kern, Andreas Straube, Tania Kümpfel

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520 |a Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and briefly review the literature. 
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