Buchumschlag

Renal sarcoidosis: epidemiological and follow-up data in a cohort of 27 patients

BACKGROUND: Renal sarcoidosis (RS) is a possible manifestation of systemic sarcoidosis. The clinical presentation can range from asymptomatic individuals up to acute renal failure with the necessity of renal replacement therapy. The definite diagnosis must be established by renal biopsy. - OBJECTIVE...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Löffler, Christian (VerfasserIn) , Löffler, Uta (VerfasserIn) , Tuleweit, Anika (VerfasserIn) , Waldherr, Rüdiger (VerfasserIn) , Uppenkamp, Michael (VerfasserIn) , Bergner, Raoul (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 January 2015
In: Sarcoidosis, vasculitis and diffuse lung diseases
Year: 2015, Jahrgang: 31, Heft: 4, Pages: 306-315
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://pubmed.ncbi.nlm.nih.gov/25591142/
Volltext
Verfasserangaben:C. Löffler, Uta Löffler, Anika Tuleweit, R. Waldherr, M. Uppenkamp, R. Bergner

MARC

LEADER 00000caa a2200000 c 4500
001 169915211X
003 DE-627
005 20241118145620.0
007 cr uuu---uuuuu
008 200602s2015 xx |||||o 00| ||eng c
035 |a (DE-627)169915211X 
035 |a (DE-599)KXP169915211X 
035 |a (OCoLC)1341327185 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Löffler, Christian  |d 1982-  |e VerfasserIn  |0 (DE-588)138751927  |0 (DE-627)605700486  |0 (DE-576)30864266X  |4 aut 
245 1 0 |a Renal sarcoidosis  |b epidemiological and follow-up data in a cohort of 27 patients  |c C. Löffler, Uta Löffler, Anika Tuleweit, R. Waldherr, M. Uppenkamp, R. Bergner 
264 1 |c 5 January 2015 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 02.06.2020 
520 |a BACKGROUND: Renal sarcoidosis (RS) is a possible manifestation of systemic sarcoidosis. The clinical presentation can range from asymptomatic individuals up to acute renal failure with the necessity of renal replacement therapy. The definite diagnosis must be established by renal biopsy. - OBJECTIVES: Demonstration of clinical characteristics and effectiveness of steroid treatment. - METHODS: We present a single center study of 27 patients with histologically proven RS. Firstly, we elaborate on descriptive features such as extra-renal organ involvement, calcium levels, renal function, proteinuria and histological subtypes and provide an histological assessment of renal damage. Secondly, we present follow-up data over a period of 2 years or more. - RESULTS: Non-granulomatous tubulointerstitial nephritis (ngIN) was the most common histological entity (44%), followed by granulomatous IN (GIN, 30%), IgA-GN (26%) and nephrocalcinosis (11%). Under treatment with oral prednisone mean eGFR significantly improved from 38 ± 21 ml/min to 57 ± 26 ml/min and proteinuria decreased from 981 ± 304 mg/24 hrs to 176 ± 77 mg/24 hrs at the end of follow-up. In total, 62.5% of patients responded to therapy. - CONCLUSIONS: We demonstrated that GIN is more often associated with advanced stages of renal insufficiency than any other histological manifestation of RS. Furthermore, prednisone therapy is effective in improving eGFR and in reducing total urinary protein secretion. We suggest that the key prognostic factor for renal survival in RS is the early response to treatment. 
650 4 |a Adult 
650 4 |a Aged 
650 4 |a Aged, 80 and over 
650 4 |a Biopsy 
650 4 |a Female 
650 4 |a Follow-Up Studies 
650 4 |a Germany 
650 4 |a Glomerular Filtration Rate 
650 4 |a Glomerulonephritis, IGA 
650 4 |a Glucocorticoids 
650 4 |a Humans 
650 4 |a Kidney 
650 4 |a Kidney Diseases 
650 4 |a Male 
650 4 |a Middle Aged 
650 4 |a Nephritis, Interstitial 
650 4 |a Prednisone 
650 4 |a Proteinuria 
650 4 |a Recovery of Function 
650 4 |a Remission Induction 
650 4 |a Renal Insufficiency 
650 4 |a Retrospective Studies 
650 4 |a Sarcoidosis 
650 4 |a Time Factors 
650 4 |a Treatment Outcome 
700 1 |a Löffler, Uta  |e VerfasserIn  |0 (DE-588)1082101664  |0 (DE-627)847114171  |0 (DE-576)455108366  |4 aut 
700 1 |a Tuleweit, Anika  |e VerfasserIn  |0 (DE-588)142474835  |0 (DE-627)636296296  |0 (DE-576)330915479  |4 aut 
700 1 |a Waldherr, Rüdiger  |e VerfasserIn  |0 (DE-588)1066699135  |0 (DE-627)817805265  |0 (DE-576)426098072  |4 aut 
700 1 |a Uppenkamp, Michael  |e VerfasserIn  |0 (DE-588)172429951  |0 (DE-627)697370437  |0 (DE-576)133292703  |4 aut 
700 1 |a Bergner, Raoul  |d 1964-  |e VerfasserIn  |0 (DE-588)1076129714  |0 (DE-627)834452766  |0 (DE-576)168931583  |4 aut 
773 0 8 |i Enthalten in  |t Sarcoidosis, vasculitis and diffuse lung diseases  |d Fidenza : Mattioli, 2008  |g 31(2015), 4, Seite 306-315  |h Online-Ressource  |w (DE-627)624822575  |w (DE-600)2549850-2  |w (DE-576)322443342  |7 nnas  |a Renal sarcoidosis epidemiological and follow-up data in a cohort of 27 patients 
773 1 8 |g volume:31  |g year:2015  |g number:4  |g pages:306-315  |g extent:10  |a Renal sarcoidosis epidemiological and follow-up data in a cohort of 27 patients 
856 4 0 |u https://pubmed.ncbi.nlm.nih.gov/25591142/  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200602 
993 |a Article 
994 |a 2015 
998 |g 1076129714  |a Bergner, Raoul  |m 1076129714:Bergner, Raoul  |d 60000  |e 60000PB1076129714  |k 0/60000/  |p 6  |y j 
998 |g 172429951  |a Uppenkamp, Michael  |m 172429951:Uppenkamp, Michael  |p 5 
998 |g 1066699135  |a Waldherr, Rüdiger  |m 1066699135:Waldherr, Rüdiger  |d 50000  |e 50000PW1066699135  |k 0/50000/  |p 4 
998 |g 142474835  |a Tuleweit, Anika  |m 142474835:Tuleweit, Anika  |p 3 
998 |g 1082101664  |a Löffler, Uta  |m 1082101664:Löffler, Uta  |d 100000  |d 100200  |e 100000PL1082101664  |e 100200PL1082101664  |k 0/100000/  |k 1/100000/100200/  |p 2 
998 |g 138751927  |a Löffler, Christian  |m 138751927:Löffler, Christian  |d 60000  |d 61400  |e 60000PL138751927  |e 61400PL138751927  |k 0/60000/  |k 1/60000/61400/  |p 1  |x j 
999 |a KXP-PPN169915211X  |e 3681339163 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"Renal sarcoidosis","subtitle":"epidemiological and follow-up data in a cohort of 27 patients","title_sort":"Renal sarcoidosis"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"169915211X","origin":[{"dateIssuedDisp":"5 January 2015","dateIssuedKey":"2015"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"624822575","origin":[{"publisherPlace":"Fidenza","publisher":"Mattioli","dateIssuedDisp":"2008-","dateIssuedKey":"2008"}],"note":["Gesehen am 22.07.21"],"disp":"Renal sarcoidosis epidemiological and follow-up data in a cohort of 27 patientsSarcoidosis, vasculitis and diffuse lung diseases","id":{"zdb":["2549850-2"],"eki":["624822575"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["Nachgewiesen 25.2008 -"],"language":["eng"],"part":{"volume":"31","year":"2015","text":"31(2015), 4, Seite 306-315","issue":"4","pages":"306-315","extent":"10"},"title":[{"title_sort":"Sarcoidosis, vasculitis and diffuse lung diseases","title":"Sarcoidosis, vasculitis and diffuse lung diseases","subtitle":"official journal of WASOG"}]}],"note":["Gesehen am 02.06.2020"],"physDesc":[{"extent":"10 S."}],"id":{"eki":["169915211X"]},"name":{"displayForm":["C. Löffler, Uta Löffler, Anika Tuleweit, R. Waldherr, M. Uppenkamp, R. Bergner"]},"person":[{"family":"Löffler","given":"Christian","role":"aut","display":"Löffler, Christian"},{"given":"Uta","role":"aut","display":"Löffler, Uta","family":"Löffler"},{"display":"Tuleweit, Anika","role":"aut","given":"Anika","family":"Tuleweit"},{"family":"Waldherr","display":"Waldherr, Rüdiger","given":"Rüdiger","role":"aut"},{"family":"Uppenkamp","role":"aut","given":"Michael","display":"Uppenkamp, Michael"},{"display":"Bergner, Raoul","role":"aut","given":"Raoul","family":"Bergner"}]} 
SRT |a LOEFFLERCHRENALSARCO5201 

Ähnliche Einträge