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Qualitative and quantitative image analysis of CT and MR imaging in patients with neuroendocrine liver metastases in comparison to 68Ga-DOTATOC PET

Purpose - To compare lesion conspicuity in patients with liver metastases arising from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) using MRI, PET and CT. - Materials and methods - 16 patients with GEP-NETs were evaluated using non-contrast MRI, contrast-enhanced (CE) MRI using Gd-EOB-DTP...

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Main Authors: Flechsig, Paul (Author) , Zechmann, Christian (Author) , Schreiweis, Julian (Author) , Kratochwil, Clemens (Author) , Rath, Daniel (Author) , Schwartz, Lawrence H. (Author) , Schlemmer, Heinz-Peter (Author) , Kauczor, Hans-Ulrich (Author) , Haberkorn, Uwe (Author) , Giesel, Frederik L. (Author)
Format: Article (Journal)
Language:English
Published: 8 May 2015
In: European journal of radiology
Year: 2015, Volume: 84, Issue: 8, Pages: 1593-1600
ISSN:1872-7727
DOI:10.1016/j.ejrad.2015.04.009
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejrad.2015.04.009
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X15001837
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Author Notes:Paul Flechsig, Christian M. Zechmann, Julian Schreiweis, Clemens Kratochwil, Daniel Rath, Lawrence H. Schwartz, Heinz-Peter Schlemmer, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L. Giesel
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Summary:Purpose - To compare lesion conspicuity in patients with liver metastases arising from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) using MRI, PET and CT. - Materials and methods - 16 patients with GEP-NETs were evaluated using non-contrast MRI, contrast-enhanced (CE) MRI using Gd-EOB-DTPA and CE-68Ga-DOTATOC PET. Quantitative analyses were performed by two blinded readers using ROI-analyses quantifying contrast ratios (CR) between normal liver-tissue and GEP-NET-metastases. Qualitative analyses were performed evaluating primary visibility and spatial detectability of all lesions. - Results - 103 of the same liver metastases were detected on all modalities. Qualitatively, lesion conspicuity was superior on CE-MRI imaging compared to non-contrast MR-sequences (T2, DWI, fl2D, fl3D), as well as arterial- and portal-venous phase CT. Concerning detectability of lesions, CE-MRI was superior to all other modalities. The quantitative ROI-analysis demonstrated improved CR for DWI compared to all other non-contrast MR-sequences (p<0.001). CE-MRI presented with higher CR-values compared to CE-68Ga-DOTATOC PET/CT (p<0.001). - Conclusions - Anatomic imaging using non contrast MRI with fl2D-and fl3D-sequences in combination with the molecular imaging modality 68Ga-DOTATOC PET is optimal for the assessment of liver lesions in GEP-NET-patients. Even though CE-MRI was superior to non-contrast MRI, non-contrast MRI is sufficient to detect and quantify liver metastases in daily routine, especially in combination with DW-Imaging.
Item Description:Im Titel ist "68" hochgestellt
Gesehen am 02.06.2020
Physical Description:Online Resource
ISSN:1872-7727
DOI:10.1016/j.ejrad.2015.04.009

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