Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits
Spatial working memory (SWM) is an essential cognitive function important for survival in a competitive environment. In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gr...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
11 July 2016
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| In: |
Neurobiology of learning and memory
Year: 2016, Jahrgang: 135, Pages: 83-90 |
| ISSN: | 1095-9564 |
| DOI: | 10.1016/j.nlm.2016.07.005 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.nlm.2016.07.005 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1074742716301058 
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| Verfasserangaben: | Florian Freudenberg, Evgeny Resnik, Alexander Kolleker, Tansu Celikel, Rolf Sprengel, Peter H. Seeburg |
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| 245 | 1 | 0 | |a Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits |c Florian Freudenberg, Evgeny Resnik, Alexander Kolleker, Tansu Celikel, Rolf Sprengel, Peter H. Seeburg |
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| 520 | |a Spatial working memory (SWM) is an essential cognitive function important for survival in a competitive environment. In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1−/− mice). Here we used viral gene transfer to show that re-expression of GluA1 in the hippocampus can affect the behavioral performance of GluA1 deficient mice. We found that Gria1−/− mice with hippocampus-specific rescue of GluA1 expression (Gria1Hpc mice) are more anxious, less hyperactive and only partly impaired in SWM expression in the Y-maze spatial novelty preference paradigm compared to Gria1−/− mice. However, Gria1Hpc mice still express SWM performance deficits when tested in the rewarded alternation T-maze task. Thus, the restoration of hippocampal function affects several behaviors of GluA1 deficient mice - including SWM expression - in different tasks. The virus-mediated GluA1 expression in Gria1−/− mice is not sufficient for a comprehensive SWM restoration, suggesting that both hippocampal as well as extra-hippocampal GluA1-containing AMPA receptors contribute to SWM. | ||
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