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Significance of the extent of intestinal resection on the outcome of a short-bowel syndrome in a porcine model

Aim of the study: Insufficient data are available to determine the most suitable extent of intestinal resection required to induce short-bowel syndrome (SBS) in pigs. This study aimed to compare the three main SBS-models published. Methods: A 75%, 90%, or 100% mid-intestinal resection was performed...

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Main Authors: Frongia, Giovanni (Author) , Nickkholgh, Arash (Author) , Hafezi, Mohammadreza (Author) , Arvin, Jalal (Author) , Saffari, Arash (Author) , Golriz, Mohammad (Author) , Aydin, Esvad (Author) , Weih, Sandra (Author) , Kessler, Markus (Author) , Emami, Golnaz (Author) , Garoussi, Camelia (Author) , Okun, Jürgen G. (Author) , Schmidt, Kathrin V. (Author) , Thiel, Christian (Author) , Brune, Maik (Author) , Günther, Patrick (Author) , Holland-Cunz, Stefan (Author) , Mehrabi, Arianeb (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Journal of investigative surgery
Year: 2016, Volume: 29, Issue: 1, Pages: 57-65
ISSN:1521-0553
DOI:10.3109/08941939.2015.1057304
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/08941939.2015.1057304
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Author Notes:Giovanni Frongia, MD, Arash Nickkholgh, MD, Mohammad Reza Hafezi M, MD, Jalal Arvin, MD, Arash Saffari, MD, Mohammad Golriz, MD, Esvad Aydin, MD, Sandra Weih, MD, Markus Kessler, MD, Golnaz Emami, MD, Camelia Garoussi, MD, Jürgen G. Okun, PhD, Kathrin Schmidt, Christian Thiel, MD PhD, Maik Brune, MD, Patrick Günther, MD, Stefan Holland-Cunz, MD, Arianeb Mehrabi, MD

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520 |a Aim of the study: Insufficient data are available to determine the most suitable extent of intestinal resection required to induce short-bowel syndrome (SBS) in pigs. This study aimed to compare the three main SBS-models published. Methods: A 75%, 90%, or 100% mid-intestinal resection was performed in groups of n = 5 pigs each. Clinical (body weight, stool consistency) and biochemical (serum eletrolytes, citrulline, albumin, prealbumin, and transferrin) parameters were determined daily, functional (D-xylose resorption) and histological (intestinal villus length) parameters were determined after 2 weeks. A t-test and ANOVA were used for statistical analysis. Results: Only in the 100% group, we observed a persistent weight loss (13.6 ± 3.8%) and diarrhea, as well as a decrease in prealbumin-levels (41%) and transferrin levels (33%). Serum electrolytes remained stable in all groups during the observation period. Citrulline stabilized at different levels (100% group 13.9 ± 1.0 μmol/L; 90% group 18.8 ± 1.0 μmol/L; 75% group 26.3 ± 1.4 μmol/L; all p < .05). D-xylose resorption was lowest in the 100%, followed by 90% and 75% group (100% group 32.8 ± 4.9 mg/L; 90% group 50.0 ± 19.6 mg/L; 75% group 57.8 ± 8.8 mg/L; p = .393). Intestinal villus length decreased in all groups (100% group 11.0%; 90% group 14.0%; 75% group 19.1%). Conclusions: 75% intestinal resection is less suitable as an SBS model, as animals tend to recover remarkably. The 90% model is suitable for longer-term studies, as animals might survive longer due to partial compensation. Due to severe nutritional, biochemical, and physiological derangements, the 100% model can only be used for acute experiments and those immediately followed by small bowel transplantation. 
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