The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 February 2015
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| In: |
Molecular and Cellular Pediatrics
Year: 2015, Volume: 2, Issue: 1 |
| ISSN: | 2194-7791 |
| DOI: | 10.1186/s40348-015-0014-6 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s40348-015-0014-6 |
| Author Notes: | Ines Mack, Andreas Hector, Marlene Ballbach, Julius Kohlhäufl, Katharina J. Fuchs, Alexander Weber, Marcus A. Mall and Dominik Hartl |
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| 520 | |a Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. | ||
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