Initial clinical evaluation of PET-based ion beam therapy monitoring under consideration of organ motion
Purpose: Intrafractional organ motion imposes considerable challenges to scanned ion beam therapy and demands for a thorough verification of the applied treatment. At the Heidelberg Ion-Beam Therapy Center (HIT), the scanned ion beam delivery is verified by means of postirradiation positron-emission...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 January 2016
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| In: |
Medical physics
Year: 2016, Jahrgang: 43, Heft: 2, Pages: 975-982 |
| ISSN: | 2473-4209 |
| DOI: | 10.1118/1.4940356 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1118/1.4940356 Verlag, lizenzpflichtig, Volltext: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1118/1.4940356 
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| Verfasserangaben: | Christopher Kurz, Julia Bauer, Daniel Unholtz, Daniel Richter, Klaus Herfarth, Jürgen Debus, Katia Parodi |
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| 245 | 1 | 0 | |a Initial clinical evaluation of PET-based ion beam therapy monitoring under consideration of organ motion |c Christopher Kurz, Julia Bauer, Daniel Unholtz, Daniel Richter, Klaus Herfarth, Jürgen Debus, Katia Parodi |
| 264 | 1 | |c 28 January 2016 | |
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| 520 | |a Purpose: Intrafractional organ motion imposes considerable challenges to scanned ion beam therapy and demands for a thorough verification of the applied treatment. At the Heidelberg Ion-Beam Therapy Center (HIT), the scanned ion beam delivery is verified by means of postirradiation positron-emission-tomography (PET) imaging. This work presents a first clinical evaluation of PET-based treatment monitoring in ion beam therapy under consideration of target motion. Methods: Three patients with mobile liver lesions underwent scanned carbon ion irradiation at HIT and postirradiation PET/CT (x-ray-computed-tomography) imaging with a commercial scanner. Respiratory motion was recorded during irradiation and subsequent image acquisition. This enabled a time-resolved (4D) calculation of the expected irradiation-induced activity pattern and, for one patient where an additional 4D CT was acquired at the PET/CT scanner after treatment, a motion-compensated PET image reconstruction. For the other patients, PET data were reconstructed statically. To verify the treatment, calculated prediction and reconstructed measurement were compared with a focus on the ion beam range. Results: Results in the current three patients suggest that for motion amplitudes in the order of 2 mm there is no benefit from incorporating respiratory motion information into PET-based treatment monitoring. For a target motion in the order of 10 mm, motion-related effects become more severe and a time-resolved modeling of the expected activity distribution can lead to an improved data interpretation if a sufficient number of true coincidences is detected. Benefits from motion-compensated PET image reconstruction could not be shown conclusively at the current stage. Conclusions: The feasibility of clinical PET-based treatment verification under consideration of organ motion has been shown for the first time. Improvements in noise-robust 4D PET image reconstruction are deemed necessary to enhance the clinical potential. | ||
| 650 | 4 | |a Analysis of motion | |
| 650 | 4 | |a Biological material | |
| 650 | 4 | |a Biomedical modeling | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Computed tomography | |
| 650 | 4 | |a Computerised tomographs | |
| 650 | 4 | |a computerised tomography | |
| 650 | 4 | |a diagnostic radiography | |
| 650 | 4 | |a Digital computing or data processing equipment or methods | |
| 650 | 4 | |a Digital radiography | |
| 650 | 4 | |a e.g. blood | |
| 650 | 4 | |a Haemocytometers | |
| 650 | 4 | |a Image data processing or generation | |
| 650 | 4 | |a image reconstruction | |
| 650 | 4 | |a in general | |
| 650 | 4 | |a ion beam therapy | |
| 650 | 4 | |a Ion beams | |
| 650 | 4 | |a liver | |
| 650 | 4 | |a Liver | |
| 650 | 4 | |a lung | |
| 650 | 4 | |a Measuring half-life of a radioactive substance | |
| 650 | 4 | |a medical image processing | |
| 650 | 4 | |a Medical image reconstruction | |
| 650 | 4 | |a Medical X-ray imaging | |
| 650 | 4 | |a motion compensation | |
| 650 | 4 | |a object detection | |
| 650 | 4 | |a organ motion | |
| 650 | 4 | |a PET | |
| 650 | 4 | |a Pneumodyamics | |
| 650 | 4 | |a pneumodynamics | |
| 650 | 4 | |a positron emission tomography | |
| 650 | 4 | |a Positron emission tomography | |
| 650 | 4 | |a Positron emission tomography (PET) | |
| 650 | 4 | |a radiation therapy | |
| 650 | 4 | |a Radiation therapy | |
| 650 | 4 | |a Reconstruction | |
| 650 | 4 | |a respiration | |
| 650 | 4 | |a Scintigraphy | |
| 650 | 4 | |a specially adapted for specific applications | |
| 650 | 4 | |a treatment monitoring | |
| 650 | 4 | |a Treatment strategy | |
| 650 | 4 | |a urine | |
| 700 | 1 | |a Bauer, Julia |e VerfasserIn |0 (DE-588)107489099X |0 (DE-627)832650145 |0 (DE-576)443090904 |4 aut | |
| 700 | 1 | |a Unholtz, Daniel |e VerfasserIn |0 (DE-588)139739645 |0 (DE-627)703447939 |0 (DE-576)312918836 |4 aut | |
| 700 | 1 | |a Richter, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herfarth, Klaus |e VerfasserIn |0 (DE-588)1032757582 |0 (DE-627)739273116 |0 (DE-576)171352289 |4 aut | |
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| 700 | 1 | |a Parodi, Katia |d 1975- |e VerfasserIn |0 (DE-588)129736996 |0 (DE-627)707308917 |0 (DE-576)188641688 |4 aut | |
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