Progress towards generation of human haematopoietic stem cells
De novo generation of haematopoietic stem cells from different human pluripotent stem cell sources remains a high priority for haematology and regenerative medicine. At present, efficient derivation of functional haematopoietic stem cells with the capability for definitive in vivo engraftment and mu...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 October 2016
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| In: |
Nature cell biology
Year: 2016, Jahrgang: 18, Heft: 11, Pages: 1111-1117 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/ncb3419 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncb3419 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncb3419 
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| Verfasserangaben: | Lara Wahlster and George Q. Daley |
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| 520 | |a De novo generation of haematopoietic stem cells from different human pluripotent stem cell sources remains a high priority for haematology and regenerative medicine. At present, efficient derivation of functional haematopoietic stem cells with the capability for definitive in vivo engraftment and multi-lineage potential remains challenging. Here, we discuss recent progress and strategies to overcome obstacles that have thwarted past efforts. In addition, we review promising advances in the generation of mature blood lineages and the potential of induced pluripotent stem cells. | ||
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