Buchumschlag

Clinical characteristics, surgical management and adjuvant therapy of patients with uterine carcinosarcoma: a retrospective case series = Klinische Charakteristika, operatives Management und adjuvante Therapie von Patientinnen mit uterinen Karzinosarkomen : eine retrospektive Fallserie

<p> <b>Purpose:</b> To review a single-center experience over a 27-year period of managing uterine carcinosarcoma (UCS), focusing on surgical practice, adjuvant therapy and clinical outcome. <b>Material and Methods:</b> This was a retrospective study of women with histo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wallwiener, Christian Wilhelm (VerfasserIn) , Hartkopf, A. (VerfasserIn) , Kommoss, S. (VerfasserIn) , Joachim, C. (VerfasserIn) , Wallwiener, Markus (VerfasserIn) , Taran, F. A. (VerfasserIn) , Brucker, S. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2016]
In: Geburtshilfe und Frauenheilkunde
Year: 2016, Jahrgang: 76, Heft: 2, Pages: 188-193
ISSN:1438-8804
DOI:10.1055/s-0042-100205
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/s-0042-100205
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-100205
Volltext
Verfasserangaben:C. Wallwiener, A. Hartkopf, S. Kommoss, C. Joachim, M. Wallwiener, F.A. Taran, S. Brucker
Beschreibung
Zusammenfassung:<p> <b>Purpose:</b> To review a single-center experience over a 27-year period of managing uterine carcinosarcoma (UCS), focusing on surgical practice, adjuvant therapy and clinical outcome. <b>Material and Methods:</b> This was a retrospective study of women with histologically proven UCS treated at the Department of Obstetrics and Gynecology, University of Tübingen, Germany, between 1983 and 2010. Inpatient and outpatient records were reviewed; follow-up and survival data were ascertained. <b>Results:</b> The study population comprised 18 patients with UCS. Primary surgical treatment consisted of total abdominal hysterectomy in 12 patients (67 %) and laparoscopic total hysterectomy in 4 patients (22 %). Bilateral salpingo-oophorectomy was performed in 94 % of patients (17/18). Lymph nodes were evaluated in 15 patients (83 %). Positive pelvic lymph nodes were present in 2 patients (11 %). A total of 17 patients (94 %) received adjuvant therapy. Disease recurred in 7 (39 %) patients of our study group, with no recurrence noted in the 4 patients who underwent laparoscopic surgical staging. Median disease-free survival (DFS) was 48.7 months (95 % CI: 0.0-157.3) and median overall survival (OS) was 49.9 months (95 % CI: 0.0-108.2). The 5-year survival rate was 40 %. <b>Conclusion:</b> UCS is a rare and aggressive uterine neoplasm with high recurrence rates and metastatic potential. Surgical staging consisting of total hysterectomy with bilateral salpingo-oophorectomy and systematic lymphadenectomy is the most important treatment for patients with UCS. Adjuvant radiation therapy appears to decrease pelvic recurrence, but there is a high incidence of distant recurrence, indicating the need for additional systemic treatment.</p>
Beschreibung:Gesehen am 05.06.2020
Beschreibung:Online Resource
ISSN:1438-8804
DOI:10.1055/s-0042-100205

Ähnliche Einträge