Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction
Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, f...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 31, 2015
|
| In: |
Mediators of inflammation
|
| ISSN: | 1466-1861 |
| DOI: | 10.1155/2015/408935 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2015/408935 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397025/ 
|
| Verfasserangaben: | Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, and Dominik Hartl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700130447 | ||
| 003 | DE-627 | ||
| 005 | 20241224005143.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200608s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2015/408935 |2 doi | |
| 035 | |a (DE-627)1700130447 | ||
| 035 | |a (DE-599)KXP1700130447 | ||
| 035 | |a (OCoLC)1341339040 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Marcos-Nickol, Veronica |d 1983- |e VerfasserIn |0 (DE-588)138459126 |0 (DE-627)602595975 |0 (DE-576)307668304 |4 aut | |
| 245 | 1 | 0 | |a Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction |c Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, and Dominik Hartl |
| 264 | 1 | |c March 31, 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.06.2020 | ||
| 520 | |a Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). NETs have been described to act in a beneficial way for innate host defense by bactericidal, fungicidal, and virucidal actions. On the other hand, excessive NET formation has been linked to the pathogenesis of autoinflammatory and autoimmune disease conditions. We quantified free DNA structures characteristic of NETs in airway fluids of CF patients and a mouse model with CF-like lung disease. Free DNA levels correlated with airflow obstruction, fungal colonization, and CXC chemokine levels in CF patients and CF-like mice. When viewed in combination, our results demonstrate that neutrophilic inflammation in CF airways is associated with abundant free DNA characteristic for NETosis, and suggest that free DNA may be implicated in lung function decline in patients with CF. | ||
| 700 | 1 | |a Zhou-Suckow, Zhe |e VerfasserIn |0 (DE-588)1067640916 |0 (DE-627)819046817 |0 (DE-576)426810031 |4 aut | |
| 700 | 1 | |a Önder Yildirim, Ali |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bohla, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hector, Andreas |d 1977- |e VerfasserIn |0 (DE-588)134244559 |0 (DE-627)565613340 |0 (DE-576)300399448 |4 aut | |
| 700 | 1 | |a Vitkov, Ljubomir |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krautgartner, Wolf Dietrich |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Stoiber, Walter |e VerfasserIn |0 (DE-588)1133037283 |0 (DE-627)888181612 |0 (DE-576)489066305 |4 aut | |
| 700 | 1 | |a Griese, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eickelberg, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mall, Marcus A. |d 1975- |e VerfasserIn |0 (DE-588)115507795 |0 (DE-627)691370532 |0 (DE-576)28992152X |4 aut | |
| 700 | 1 | |a Hartl, Dominik |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mediators of inflammation |d [Hoboken, NJ] : Wiley, 1992 |g (2015) Artikel-Nummer 408935, 11 Seiten |h Online-Ressource |w (DE-627)320467384 |w (DE-600)2008065-7 |w (DE-576)273878204 |x 1466-1861 |7 nnas |a Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction |
| 773 | 1 | 8 | |g year:2015 |a Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction |
| 856 | 4 | 0 | |u https://doi.org/10.1155/2015/408935 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397025/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20200608 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 115507795 |a Mall, Marcus A. |m 115507795:Mall, Marcus A. |d 910000 |d 910500 |e 910000PM115507795 |e 910500PM115507795 |k 0/910000/ |k 1/910000/910500/ |p 11 | ||
| 998 | |g 1067640916 |a Zhou-Suckow, Zhe |m 1067640916:Zhou-Suckow, Zhe |d 910000 |d 910500 |e 910000PZ1067640916 |e 910500PZ1067640916 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 999 | |a KXP-PPN1700130447 |e 3684237116 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1700130447","language":["eng"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"[Hoboken, NJ] ; London ; Sylvania, Ohio","publisher":"Wiley ; Taylor & Francis ; Hindawi Publishing Corp.","dateIssuedKey":"2024","dateIssuedDisp":"2024-"}],"id":{"issn":["1466-1861"],"zdb":["2008065-7"],"doi":["10.1155/MI"],"eki":["320467384"]},"pubHistory":["1.1992-"],"part":{"text":"(2015) Artikel-Nummer 408935, 11 Seiten","volume":"(2015) Artikel-Nummer 408935","issue":"11 Seiten","year":"2015"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 29.01.2025"],"disp":"Free DNA in cystic fibrosis airway fluids correlates with airflow obstructionMediators of inflammation","recId":"320467384","language":["eng"],"title":[{"title":"Mediators of inflammation","title_sort":"Mediators of inflammation"}]}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.06.2020"],"id":{"eki":["1700130447"],"doi":["10.1155/2015/408935"]},"title":[{"title_sort":"Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction","title":"Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction"}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"March 31, 2015"}],"person":[{"roleDisplay":"VerfasserIn","display":"Marcos-Nickol, Veronica","role":"aut","family":"Marcos-Nickol","given":"Veronica"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zhou-Suckow, Zhe","given":"Zhe","family":"Zhou-Suckow"},{"role":"aut","display":"Önder Yildirim, Ali","roleDisplay":"VerfasserIn","given":"Ali","family":"Önder Yildirim"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Bohla, Alexander","given":"Alexander","family":"Bohla"},{"family":"Hector","given":"Andreas","roleDisplay":"VerfasserIn","display":"Hector, Andreas","role":"aut"},{"family":"Vitkov","given":"Ljubomir","roleDisplay":"VerfasserIn","display":"Vitkov, Ljubomir","role":"aut"},{"given":"Wolf Dietrich","family":"Krautgartner","role":"aut","display":"Krautgartner, Wolf Dietrich","roleDisplay":"VerfasserIn"},{"given":"Walter","family":"Stoiber","role":"aut","roleDisplay":"VerfasserIn","display":"Stoiber, Walter"},{"given":"Matthias","family":"Griese","role":"aut","roleDisplay":"VerfasserIn","display":"Griese, Matthias"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Eickelberg, Oliver","given":"Oliver","family":"Eickelberg"},{"roleDisplay":"VerfasserIn","display":"Mall, Marcus A.","role":"aut","family":"Mall","given":"Marcus A."},{"display":"Hartl, Dominik","roleDisplay":"VerfasserIn","role":"aut","family":"Hartl","given":"Dominik"}],"name":{"displayForm":["Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, and Dominik Hartl"]}} | ||
| SRT | |a MARCOSNICKFREEDNAINC3120 | ||