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LIM homeobox protein 5 (Lhx5) is essential for mamillary body development

The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is require...

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Main Authors: Miquelajauregui Graf, Amaya (Author) , Heide, Michael (Author) , Alvarez-Bolado, Gonzalo (Author)
Format: Article (Journal)
Language:English
Published: 27 October 2015
In: Frontiers in neuroanatomy
Year: 2015, Volume: 9
ISSN:1662-5129
DOI:10.3389/fnana.2015.00136
Online Access:Verlag, Volltext: https://doi.org/10.3389/fnana.2015.00136
Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fnana.2015.00136/full
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Author Notes:Amaya Miquelajáuregui, Teresa Sandoval-Schaefer, Miriam Martínez-Armenta, Leonor Pérez-Martínez, Alfonso Cárabez, Yangu Zhao, Michael Heide, Gonzalo Alvarez-Bolado and Alfredo Varela-Echavarría

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520 |a The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts. The MM markers Foxb1, Sim2 and Lhx1 are absent in Lhx5 knock-out mice from early embryonic stages, suggesting abnormal specification of this region. This was supported by the absence of Nkx2.1 and expansion of Shh in the prospective mamillary area. Interestingly, we also found an ectopic domain expressing Lhx2 and Lhx9 along the anterio-posterior hypothalamic axis. Our results suggest that Lhx5 controls early aspects of hypothalamic development by regulating gene expression and cellular specification in the prospective MM. 
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