The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been described in diffe...

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Hauptverfasser: Mátyás, Csaba (VerfasserIn) , Németh, Balázs Tamás (VerfasserIn) , Oláh, Attila (VerfasserIn) , Hidi, László (VerfasserIn) , Birtalan, Ede (VerfasserIn) , Kellermayer, Dalma (VerfasserIn) , Ruppert, Mihály (VerfasserIn) , Korkmaz-İçöz, Sevil (VerfasserIn) , Kökény, Gábor (VerfasserIn) , Horváth, Eszter Mária (VerfasserIn) , Szabó, Gábor (VerfasserIn) , Merkely, Béla (VerfasserIn) , Radovits, Tamás (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 31 October 2015
In: Cardiovascular diabetology
Year: 2015, Jahrgang: 14, Heft: 1
ISSN:1475-2840
DOI:10.1186/s12933-015-0309-x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12933-015-0309-x
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Verfasserangaben:Csaba Mátyás, Balázs Tamás Németh, Attila Oláh, László Hidi, Ede Birtalan, Dalma Kellermayer, Mihály Ruppert, Sevil Korkmaz-Icöz, Gábor Kökény, Eszter Mária Horváth, Gábor Szabó, Béla Merkely and Tamás Radovits
Beschreibung
Zusammenfassung:Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been described in different heart diseases. In the current study we aimed at investigating the effects of pharmacological activation of sGC in diabetic cardiomyopathy.
Beschreibung:Gesehen am 09.06.2020
Beschreibung:Online Resource
ISSN:1475-2840
DOI:10.1186/s12933-015-0309-x