Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

Intramembrane proteolysis - cleavage of proteins within the plane of a membrane - is a widespread phenomenon that can contribute to the functional activation of substrates and is involved in several diseases. Although different families of intramembrane proteases have been discovered and characteriz...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Langosch, Dieter (VerfasserIn) , Scharnagl, C. (VerfasserIn) , Steiner, H. (VerfasserIn) , Lemberg, Marius (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 May 2015
In: Trends in biochemical sciences
Year: 2015, Jahrgang: 40, Heft: 6, Pages: 318-327
ISSN:1362-4326
DOI:10.1016/j.tibs.2015.04.001
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibs.2015.04.001
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968000415000663
Volltext
Verfasserangaben:D. Langosch, C. Scharnagl, H. Steiner, and M.K. Lemberg

MARC

LEADER 00000caa a2200000 c 4500
001 1700241796
003 DE-627
005 20230427020030.0
007 cr uuu---uuuuu
008 200609s2015 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.tibs.2015.04.001  |2 doi 
035 |a (DE-627)1700241796 
035 |a (DE-599)KXP1700241796 
035 |a (OCoLC)1341339319 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Langosch, Dieter  |d 1958-  |e VerfasserIn  |0 (DE-588)1207481556  |0 (DE-627)1693815486  |4 aut 
245 1 0 |a Understanding intramembrane proteolysis  |b from protein dynamics to reaction kinetics  |c D. Langosch, C. Scharnagl, H. Steiner, and M.K. Lemberg 
264 1 |c 1 May 2015 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 09.06.2020 
520 |a Intramembrane proteolysis - cleavage of proteins within the plane of a membrane - is a widespread phenomenon that can contribute to the functional activation of substrates and is involved in several diseases. Although different families of intramembrane proteases have been discovered and characterized, we currently do not know how these enzymes discriminate between substrates and non-substrates, how site-specific cleavage is achieved, or which factors determine the rate of proteolysis. Focusing on γ-secretase and rhomboid proteases, we argue that answers to these questions may emerge from connecting experimental readouts, such as reaction kinetics and the determination of cleavage sites, to the structures and the conformational dynamics of substrates and enzymes. 
650 4 |a conformational dynamics 
650 4 |a intramembrane proteolysis/protease 
650 4 |a presenilin 
650 4 |a rhomboid 
650 4 |a transmembrane helix 
650 4 |a γ-secretase 
700 1 |a Scharnagl, C.  |e VerfasserIn  |4 aut 
700 1 |a Steiner, H.  |e VerfasserIn  |4 aut 
700 1 |a Lemberg, Marius  |e VerfasserIn  |0 (DE-588)1063794293  |0 (DE-627)812604490  |0 (DE-576)422912328  |4 aut 
773 0 8 |i Enthalten in  |t Trends in biochemical sciences  |d Amsterdam [u.a.] : Elsevier Science, 1976  |g 40(2015), 6, Seite 318-327  |h Online-Ressource  |w (DE-627)306593068  |w (DE-600)1498901-3  |w (DE-576)094113513  |x 1362-4326  |7 nnas  |a Understanding intramembrane proteolysis from protein dynamics to reaction kinetics 
773 1 8 |g volume:40  |g year:2015  |g number:6  |g pages:318-327  |g extent:10  |a Understanding intramembrane proteolysis from protein dynamics to reaction kinetics 
856 4 0 |u https://doi.org/10.1016/j.tibs.2015.04.001  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0968000415000663  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200609 
993 |a Article 
994 |a 2015 
998 |g 1063794293  |a Lemberg, Marius  |m 1063794293:Lemberg, Marius  |d 700000  |d 706000  |e 700000PL1063794293  |e 706000PL1063794293  |k 0/700000/  |k 1/700000/706000/  |p 4  |y j 
999 |a KXP-PPN1700241796  |e 3684709387 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"10 S."}],"person":[{"family":"Langosch","given":"Dieter","display":"Langosch, Dieter","role":"aut"},{"role":"aut","display":"Scharnagl, C.","family":"Scharnagl","given":"C."},{"display":"Steiner, H.","role":"aut","family":"Steiner","given":"H."},{"role":"aut","display":"Lemberg, Marius","given":"Marius","family":"Lemberg"}],"title":[{"title":"Understanding intramembrane proteolysis","title_sort":"Understanding intramembrane proteolysis","subtitle":"from protein dynamics to reaction kinetics"}],"relHost":[{"titleAlt":[{"title":"TIBS"}],"disp":"Understanding intramembrane proteolysis from protein dynamics to reaction kineticsTrends in biochemical sciences","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"part":{"issue":"6","pages":"318-327","text":"40(2015), 6, Seite 318-327","extent":"10","volume":"40","year":"2015"},"corporate":[{"display":"International Union of Biochemistry and Molecular Biology","role":"isb"}],"title":[{"title":"Trends in biochemical sciences","title_sort":"Trends in biochemical sciences","subtitle":"TIBS"}],"recId":"306593068","name":{"displayForm":["publ. by the International Union of Biochemistry and Molecular Biology and Elsevier Trends Journals"]},"pubHistory":["1.1976 -"],"id":{"issn":["1362-4326"],"eki":["306593068"],"zdb":["1498901-3"]},"origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1976-","dateIssuedKey":"1976","publisherPlace":"Amsterdam [u.a.]"}],"note":["Gesehen am 28.05.20"],"physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"1 May 2015","dateIssuedKey":"2015"}],"note":["Gesehen am 09.06.2020"],"id":{"doi":["10.1016/j.tibs.2015.04.001"],"eki":["1700241796"]},"name":{"displayForm":["D. Langosch, C. Scharnagl, H. Steiner, and M.K. Lemberg"]},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1700241796"} 
SRT |a LANGOSCHDIUNDERSTAND1201