Buchumschlag

FASN is a biomarker enriched in malignant glioma-derived extracellular vesicles

Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ricklefs, Franz Lennard (VerfasserIn) , Maire, Cecile L. (VerfasserIn) , Matschke, Jakob (VerfasserIn) , Dührsen, Lasse (VerfasserIn) , Sauvigny, Thomas (VerfasserIn) , Holz, Mareike (VerfasserIn) , Kolbe, Katharina (VerfasserIn) , Peine, Sven (VerfasserIn) , Herold-Mende, Christel (VerfasserIn) , Carter, Bob (VerfasserIn) , Chiocca, E. Antonio (VerfasserIn) , Lawler, Sean E. (VerfasserIn) , Westphal, Manfred (VerfasserIn) , Lamszus, Katrin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 12 March 2020
In: International journal of molecular sciences
Year: 2020, Jahrgang: 21, Heft: 6
ISSN:1422-0067
DOI:10.3390/ijms21061931
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms21061931
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/21/6/1931
Volltext
Verfasserangaben:Franz L. Ricklefs, Cecile L. Maire, Jakob Matschke, Lasse Dührsen, Thomas Sauvigny, Mareike Holz, Katharina Kolbe, Sven Peine, Christel Herold-Mende, Bob Carter, E. Antonio Chiocca, Sean E. Lawler, Manfred Westphal, Katrin Lamszus
Beschreibung
Zusammenfassung:Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
Beschreibung:Gesehen am 10.06.2020
Beschreibung:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms21061931

Ähnliche Einträge