Quantitative pulsed CEST-MRI using Ω-plots
Chemical exchange saturation transfer (CEST) allows the indirect detection of dilute metabolites in living tissue via MRI of the tissue water signal. Selective radio frequency (RF) with amplitude B1 is used to saturate the magnetization of protons of exchanging groups, which transfer the saturation...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 August 2015
|
| In: |
NMR in biomedicine
Year: 2015, Jahrgang: 28, Heft: 10, Pages: 1196-1208 |
| ISSN: | 1099-1492 |
| DOI: | 10.1002/nbm.3362 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/nbm.3362 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.3362 
|
| Verfasserangaben: | Jan-Eric Meissner, Steffen Goerke, Eugenia Rerich, Karel D. Klika, Alexander Radbruch, Mark E. Ladd, Peter Bachert, Moritz Zaiss |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700514180 | ||
| 003 | DE-627 | ||
| 005 | 20220818121107.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200612s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/nbm.3362 |2 doi | |
| 035 | |a (DE-627)1700514180 | ||
| 035 | |a (DE-599)KXP1700514180 | ||
| 035 | |a (OCoLC)1341339535 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Meißner, Jan-Eric |d 1988- |e VerfasserIn |0 (DE-588)1136148639 |0 (DE-627)891592717 |0 (DE-576)490357040 |4 aut | |
| 245 | 1 | 0 | |a Quantitative pulsed CEST-MRI using Ω-plots |c Jan-Eric Meissner, Steffen Goerke, Eugenia Rerich, Karel D. Klika, Alexander Radbruch, Mark E. Ladd, Peter Bachert, Moritz Zaiss |
| 246 | 3 | 3 | |a Quantitative pulsed CEST-MRI using omega plots |
| 264 | 1 | |c 17 August 2015 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.06.2020 | ||
| 520 | |a Chemical exchange saturation transfer (CEST) allows the indirect detection of dilute metabolites in living tissue via MRI of the tissue water signal. Selective radio frequency (RF) with amplitude B1 is used to saturate the magnetization of protons of exchanging groups, which transfer the saturation to the abundant water pool. In a clinical setup, the saturation scheme is limited to a series of short pulses to follow regulation of the specific absorption rate (SAR). Pulsed saturation is difficult to describe theoretically, thus rendering quantitative CEST a challenging task. In this study, we propose a new analytical treatment of pulsed CEST by extending a former interleaved saturation-relaxation approach. Analytical integration of the continuous wave (cw) eigenvalue as a function of the RF pulse shape leads to a formula for pulsed CEST that has the same structure as that for cw CEST, but incorporates two form factors that are determined by the pulse shape. This enables analytical Z-spectrum calculations and permits deeper insight into pulsed CEST. Furthermore, it extends Dixon's Ω-plot method to the case of pulsed saturation, yielding separately, and independently, the exchange rate and the relative proton concentration. Consequently, knowledge of the form factors allows a direct comparison of the effect of the strength and B1 dispersion of pulsed CEST experiments with the ideal case of cw saturation. The extended pulsed CEST quantification approach was verified using creatine phantoms measured on a 7 T whole-body MR tomograph, and its range of validity was assessed by simulations. Copyright © 2015 John Wiley & Sons, Ltd. | ||
| 650 | 4 | |a CEST | |
| 650 | 4 | |a creatine | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a pulsed pre-saturation | |
| 650 | 4 | |a Ω-plot | |
| 700 | 1 | |a Görke, Steffen |e VerfasserIn |0 (DE-588)1080269738 |0 (DE-627)844105791 |0 (DE-576)453447902 |4 aut | |
| 700 | 1 | |a Rerich, Eugenia |e VerfasserIn |0 (DE-588)1067833439 |0 (DE-627)819239666 |0 (DE-576)27109530X |4 aut | |
| 700 | 1 | |a Klika, Karel D. |e VerfasserIn |0 (DE-588)1202969429 |0 (DE-627)1687574782 |4 aut | |
| 700 | 1 | |a Radbruch, Alexander |d 1977- |e VerfasserIn |0 (DE-588)1022344501 |0 (DE-627)716953951 |0 (DE-576)362851166 |4 aut | |
| 700 | 1 | |a Ladd, Mark E. |e VerfasserIn |0 (DE-588)108120964X |0 (DE-627)845690507 |0 (DE-576)454039999 |4 aut | |
| 700 | 1 | |a Bachert, Peter |e VerfasserIn |0 (DE-588)1103529633 |0 (DE-627)861285824 |0 (DE-576)251203298 |4 aut | |
| 700 | 1 | |a Zaiss, Moritz |e VerfasserIn |0 (DE-588)1047655659 |0 (DE-627)778741095 |0 (DE-576)330036947 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t NMR in biomedicine |d New York, NY : Wiley, 1988 |g 28(2015), 10, Seite 1196-1208 |h Online-Ressource |w (DE-627)313117551 |w (DE-600)2002003-X |w (DE-576)096188642 |x 1099-1492 |7 nnas |a Quantitative pulsed CEST-MRI using Ω-plots |
| 773 | 1 | 8 | |g volume:28 |g year:2015 |g number:10 |g pages:1196-1208 |g extent:13 |a Quantitative pulsed CEST-MRI using Ω-plots |
| 856 | 4 | 0 | |u https://doi.org/10.1002/nbm.3362 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.3362 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200612 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1047655659 |a Zaiß, Moritz |m 1047655659:Zaiß, Moritz |d 50000 |e 50000PZ1047655659 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1103529633 |a Bachert, Peter |m 1103529633:Bachert, Peter |d 130000 |e 130000PB1103529633 |k 0/130000/ |p 7 | ||
| 998 | |g 108120964X |a Ladd, Mark E. |m 108120964X:Ladd, Mark E. |d 50000 |e 50000PL108120964X |k 0/50000/ |p 6 | ||
| 998 | |g 1022344501 |a Radbruch, Alexander |m 1022344501:Radbruch, Alexander |d 910000 |d 910100 |e 910000PR1022344501 |e 910100PR1022344501 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1136148639 |a Meißner, Jan-Eric |m 1136148639:Meißner, Jan-Eric |d 130000 |e 130000PM1136148639 |k 0/130000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1700514180 |e 3686642069 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"13 S."}],"relHost":[{"language":["eng"],"title":[{"title_sort":"NMR in biomedicine","subtitle":"an international journal devoted to the development and application of magnetic resonance in vivo","title":"NMR in biomedicine"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Quantitative pulsed CEST-MRI using Ω-plotsNMR in biomedicine","note":["Gesehen am 13.01.12"],"part":{"year":"2015","extent":"13","volume":"28","text":"28(2015), 10, Seite 1196-1208","issue":"10","pages":"1196-1208"},"pubHistory":["1.1988 -"],"id":{"doi":["10.1002/(ISSN)1099-1492"],"eki":["313117551"],"zdb":["2002003-X"],"issn":["1099-1492"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"Nuclear magnetic resonance in biomedicine"}],"recId":"313117551","origin":[{"dateIssuedKey":"1988","publisherPlace":"New York, NY","dateIssuedDisp":"1988-","publisher":"Wiley"}]}],"title":[{"title_sort":"Quantitative pulsed CEST-MRI using Ω-plots","title":"Quantitative pulsed CEST-MRI using Ω-plots"}],"language":["eng"],"person":[{"role":"aut","display":"Meißner, Jan-Eric","given":"Jan-Eric","family":"Meißner"},{"given":"Steffen","family":"Görke","role":"aut","display":"Görke, Steffen"},{"given":"Eugenia","family":"Rerich","role":"aut","display":"Rerich, Eugenia"},{"family":"Klika","given":"Karel D.","display":"Klika, Karel D.","role":"aut"},{"role":"aut","display":"Radbruch, Alexander","given":"Alexander","family":"Radbruch"},{"given":"Mark E.","family":"Ladd","role":"aut","display":"Ladd, Mark E."},{"given":"Peter","family":"Bachert","role":"aut","display":"Bachert, Peter"},{"role":"aut","display":"Zaiss, Moritz","given":"Moritz","family":"Zaiss"}],"name":{"displayForm":["Jan-Eric Meissner, Steffen Goerke, Eugenia Rerich, Karel D. Klika, Alexander Radbruch, Mark E. Ladd, Peter Bachert, Moritz Zaiss"]},"note":["Gesehen am 12.06.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1002/nbm.3362"],"eki":["1700514180"]},"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"17 August 2015"}],"titleAlt":[{"title":"Quantitative pulsed CEST-MRI using omega plots"}],"recId":"1700514180"} | ||
| SRT | |a MEISSNERJAQUANTITATI1720 | ||