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daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans

The aim of this study was to determine the protective effects of human insulin and its analogues, B28Asp human insulin (insulin aspart) and B29Lys(ε-tetradecanoyl),desB30 human insulin (insulin detemir), against glucose-induced lifespan reduction and neuronal damage in the model organism Caenorhabdi...

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Main Authors: Mendler, Michael (Author) , Ibrahim, Youssef (Author) , Kukudov, Georgi (Author) , Fleming, Thomas (Author) , Bierhaus, Angelika (Author) , Riedinger, Christin (Author) , Schwenger, Vedat (Author) , Herzig, Stephan (Author) , Hecker, Markus (Author) , Tyedmers, Jens (Author) , Nawroth, Peter Paul (Author) , Morcos, Michael (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Diabetologia
Year: 2015, Volume: 58, Issue: 2, Pages: 393-401
ISSN:1432-0428
DOI:10.1007/s00125-014-3415-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00125-014-3415-5
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Author Notes:Michael Mendler, Andreas Schlotterer, Youssef Ibrahim, Georgi Kukudov, Thomas Fleming, Angelika Bierhaus, Christin Riedinger, Vedat Schwenger, Stephan Herzig, Markus Hecker, Jens Tyedmers, Peter P. Nawroth, Michael Morcos
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Summary:The aim of this study was to determine the protective effects of human insulin and its analogues, B28Asp human insulin (insulin aspart) and B29Lys(ε-tetradecanoyl),desB30 human insulin (insulin detemir), against glucose-induced lifespan reduction and neuronal damage in the model organism Caenorhabditis elegans and to elucidate the underlying mechanisms.
Item Description:Published online: 17 October 2014
Gesehen am 12.06.2020
Physical Description:Online Resource
ISSN:1432-0428
DOI:10.1007/s00125-014-3415-5

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