Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion
Recombinant human erythropoietin (rhuEpo) is currently under debate for the treatment of chemotherapy-induced anemia due to clinical trials showing adverse effects in Epo-treated patients and the discovery of the erythropoietin-receptor (EpoR) in tumor and endothelial cells. Here, using Epo-Cy5.5 as...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015.05.01
|
| In: |
Theranostics
Year: 2015, Jahrgang: 5, Heft: 8, Pages: 905-918 |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.11304 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7150/thno.11304 Verlag, lizenzpflichtig, Volltext: http://www.thno.org/v05p0905.htm 
|
| Verfasserangaben: | Dennis Doleschel, Anne Rix, Susanne Arns, Karin Palmowski, Felix Gremse, Ruth Merkle, Florian Salopiata, Ursula Klingmüller, Michael Jarsch, Fabian Kiessling, Wiltrud Lederle |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700575414 | ||
| 003 | DE-627 | ||
| 005 | 20230427020206.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200615s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7150/thno.11304 |2 doi | |
| 035 | |a (DE-627)1700575414 | ||
| 035 | |a (DE-599)KXP1700575414 | ||
| 035 | |a (OCoLC)1341339495 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Doleschel, Dennis |d 1980- |e VerfasserIn |0 (DE-588)1088348858 |0 (DE-627)849512522 |0 (DE-576)459164430 |4 aut | |
| 245 | 1 | 0 | |a Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion |c Dennis Doleschel, Anne Rix, Susanne Arns, Karin Palmowski, Felix Gremse, Ruth Merkle, Florian Salopiata, Ursula Klingmüller, Michael Jarsch, Fabian Kiessling, Wiltrud Lederle |
| 264 | 1 | |c 2015.05.01 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.06.2020 | ||
| 520 | |a Recombinant human erythropoietin (rhuEpo) is currently under debate for the treatment of chemotherapy-induced anemia due to clinical trials showing adverse effects in Epo-treated patients and the discovery of the erythropoietin-receptor (EpoR) in tumor and endothelial cells. Here, using Epo-Cy5.5 as theranostic near-infrared fluorescent probe we analyzed the effects of rhuEpo as co-medication to carboplatin in non-small-cell-lung-cancer (NSCLC)-xenografts with different tumor cell EpoR-expression (H838 ~8-fold higher than A549). Nude mice bearing subcutaneous A549 and H838 NSCLC-xenografts received either only carboplatin or carboplatin and co-medication of rhuEpo in two different doses. Tumor sizes and relative blood volumes (rBV) were longitudinally measured by 3D-contrast-enhanced ultrasound (3D-US). Tumoral EpoR-levels were determined by combined fluorescence molecular tomography (FMT)/ micro computed tomography (µCT) hybrid imaging. We found that rhuEpo predominantly acted on the tumor endothelium. In both xenografts, rhuEpo co-medication significantly increased vessel densities, diameters and the amount of perfused vessels. Accordingly, rhuEpo induced EpoR-phoshorylation and stimulated proliferation of endothelial cells. However, compared with solely carboplatin-treated tumors, tumor growth was significantly slower in the groups co-medicated with rhuEpo. This is explained by the Epo-mediated vascular remodeling leading to improved drug delivery as obvious by a more than 2-fold higher carboplatin accumulation and significantly enhanced tumor apoptosis. In addition, co-medication of rhuEpo reduced tumor hypoxia and diminished intratumoral EpoR-levels which continuously increased during carboplatin (Cp) -treatment. These findings suggest that co-medication of rhuEpo in well balanced doses can be used to improve the accumulation of anticancer drugs. Doses and indications may be personalized and refined using theranostic EpoR-probes. | ||
| 700 | 1 | |a Rix, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arns, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Palmowski, Karin |e VerfasserIn |0 (DE-588)1058102435 |0 (DE-627)796405972 |0 (DE-576)414111885 |4 aut | |
| 700 | 1 | |a Gremse, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merkle, Ruth |e VerfasserIn |0 (DE-588)1071378902 |0 (DE-627)82581748X |0 (DE-576)433057637 |4 aut | |
| 700 | 1 | |a Schwörer, Florian |e VerfasserIn |0 (DE-588)1139307320 |0 (DE-627)897060210 |0 (DE-576)493230823 |4 aut | |
| 700 | 1 | |a Klingmüller, Ursula |d 1964- |e VerfasserIn |0 (DE-588)1098573455 |0 (DE-627)857742876 |0 (DE-576)46917014X |4 aut | |
| 700 | 1 | |a Jarsch, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kiessling, Fabian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lederle, Wiltrud |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Theranostics |d Wyoming, NSW : Ivyspring, 2011 |g 5(2015), 8, Seite 905-918 |h Online-Ressource |w (DE-627)645091030 |w (DE-600)2592097-2 |w (DE-576)336963033 |x 1838-7640 |7 nnas |a Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion |
| 773 | 1 | 8 | |g volume:5 |g year:2015 |g number:8 |g pages:905-918 |g extent:14 |a Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion |
| 856 | 4 | 0 | |u https://doi.org/10.7150/thno.11304 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.thno.org/v05p0905.htm |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200615 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1098573455 |a Klingmüller, Ursula |m 1098573455:Klingmüller, Ursula |d 140000 |d 140001 |e 140000PK1098573455 |e 140001PK1098573455 |k 0/140000/ |k 1/140000/140001/ |p 8 | ||
| 998 | |g 1139307320 |a Salopiata, Florian |m 1139307320:Salopiata, Florian |d 140000 |e 140000PS1139307320 |k 0/140000/ |p 7 | ||
| 998 | |g 1071378902 |a Merkle, Ruth |m 1071378902:Merkle, Ruth |d 140000 |e 140000PM1071378902 |k 0/140000/ |p 6 | ||
| 998 | |g 1058102435 |a Palmowski, Karin |m 1058102435:Palmowski, Karin |d 910000 |d 950000 |d 950900 |e 910000PP1058102435 |e 950000PP1058102435 |e 950900PP1058102435 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 4 | ||
| 999 | |a KXP-PPN1700575414 |e 3687285693 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Wyoming, NSW","publisher":"Ivyspring","dateIssuedKey":"2011","dateIssuedDisp":"2011-"}],"id":{"issn":["1838-7640"],"eki":["645091030"],"zdb":["2592097-2"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 11.11.20"],"disp":"Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusionTheranostics","language":["eng"],"recId":"645091030","pubHistory":["1.2011 -"],"part":{"year":"2015","issue":"8","pages":"905-918","volume":"5","text":"5(2015), 8, Seite 905-918","extent":"14"},"title":[{"title_sort":"Theranostics","title":"Theranostics"}]}],"physDesc":[{"extent":"14 S."}],"name":{"displayForm":["Dennis Doleschel, Anne Rix, Susanne Arns, Karin Palmowski, Felix Gremse, Ruth Merkle, Florian Salopiata, Ursula Klingmüller, Michael Jarsch, Fabian Kiessling, Wiltrud Lederle"]},"id":{"eki":["1700575414"],"doi":["10.7150/thno.11304"]},"origin":[{"dateIssuedDisp":"2015.05.01","dateIssuedKey":"2015"}],"recId":"1700575414","language":["eng"],"note":["Gesehen am 15.06.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"roleDisplay":"VerfasserIn","display":"Doleschel, Dennis","role":"aut","family":"Doleschel","given":"Dennis"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Rix, Anne","given":"Anne","family":"Rix"},{"family":"Arns","given":"Susanne","display":"Arns, Susanne","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Karin","family":"Palmowski","role":"aut","roleDisplay":"VerfasserIn","display":"Palmowski, Karin"},{"display":"Gremse, Felix","roleDisplay":"VerfasserIn","role":"aut","family":"Gremse","given":"Felix"},{"family":"Merkle","given":"Ruth","roleDisplay":"VerfasserIn","display":"Merkle, Ruth","role":"aut"},{"given":"Florian","family":"Schwörer","role":"aut","display":"Schwörer, Florian","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Klingmüller, Ursula","given":"Ursula","family":"Klingmüller"},{"role":"aut","display":"Jarsch, Michael","roleDisplay":"VerfasserIn","given":"Michael","family":"Jarsch"},{"family":"Kiessling","given":"Fabian","roleDisplay":"VerfasserIn","display":"Kiessling, Fabian","role":"aut"},{"family":"Lederle","given":"Wiltrud","roleDisplay":"VerfasserIn","display":"Lederle, Wiltrud","role":"aut"}],"title":[{"title":"Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion","title_sort":"Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion"}]} | ||
| SRT | |a DOLESCHELDERYTHROPOI2015 | ||