A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis
BACKGROUND: Angiogenesis is a fundamental process underlying cancer progression and autoimmune disease. Lewis Y is known as a regulated glycan-structure supporting human endothelial function and angiogenesis. - OBJECTIVES: We hypothesize that Lewis Y based analogues interfere with Lewis Y mediated e...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2015
|
| In: |
Advances in clinical and experimental medicine
Year: 2015, Jahrgang: 24, Heft: 5, Pages: 759-768 |
| ISSN: | 2451-2680 |
| DOI: | 10.17219/acem/38562 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.17219/acem/38562
|
| Verfasserangaben: | Sandra Sauer, Tobias Meissner, Thomas Moehler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700636146 | ||
| 003 | DE-627 | ||
| 005 | 20240406193212.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200616s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.17219/acem/38562 |2 doi | |
| 035 | |a (DE-627)1700636146 | ||
| 035 | |a (DE-599)KXP1700636146 | ||
| 035 | |a (OCoLC)1341339652 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sauer, Sandra |d 1975- |e VerfasserIn |0 (DE-588)1060031140 |0 (DE-627)799171778 |0 (DE-576)416132855 |4 aut | |
| 245 | 1 | 2 | |a A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis |c Sandra Sauer, Tobias Meissner, Thomas Moehler |
| 264 | 1 | |c September 2015 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.06.2020 | ||
| 520 | |a BACKGROUND: Angiogenesis is a fundamental process underlying cancer progression and autoimmune disease. Lewis Y is known as a regulated glycan-structure supporting human endothelial function and angiogenesis. - OBJECTIVES: We hypothesize that Lewis Y based analogues interfere with Lewis Y mediated endothelial functions and angiogenesis. We therefore evaluated the ability of 3, 4-bis [(b-D-galactopyranosyl)osy]-methyl-furan (BGF) a furan-based Lewis-Y saccharide mimetic to inhibit human endothelial adhesion, migration and in vitro angiogenesis. - MATERIAL AND METHODS: The ability of BGF and additional furan-based saccharide-mimetics was investigated to inhibit adhesion and migration of human bone marrow endothelial cells (HBMEC). Influence of BGF was tested on a multicelluar in vitro - angiogenesis assay in the presence of VEGF. - RESULTS: BGF significantly inhibited HBMEC adhesion and migration stimulated by TNF-alpha by up to 70%. The anti-adhesive effect of BGF was particularly evident when HBMEC adhesion and migration was tested on collagen as extracellular matrix with weaker effect when laminin and fibronectin were used as an extracellular matrix. BGF was ineffective when HBMEC were stimulated with VEGF. The inhibition of endothelial function translated into a significant inhibitory effect of BGF in the multicellular in vitro angiogenesis-assay. BGF reduced the angiogenesis index compared to the positive controls by 32%. - CONCLUSIONS: We identified the ability of the furan-based Lewis Y saccharide mimetic BGF as a specific modulator of TNF-alpha activated endothelial function and in vitro angiogenesis. BGF and other related glycan analogues should further be explored for their ability to down modulate endothelial activation in TNF-alpha driven pathophysiologic conditions in autoimmune disease and cancer indications. | ||
| 650 | 4 | |a Biomimetic Materials | |
| 650 | 4 | |a Carbohydrate Sequence | |
| 650 | 4 | |a Cell Adhesion | |
| 650 | 4 | |a Cell Line, Transformed | |
| 650 | 4 | |a Cell Movement | |
| 650 | 4 | |a Collagen | |
| 650 | 4 | |a Dose-Response Relationship, Drug | |
| 650 | 4 | |a Endothelial Cells | |
| 650 | 4 | |a Fibronectins | |
| 650 | 4 | |a Furans | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Laminin | |
| 650 | 4 | |a Lewis Blood Group Antigens | |
| 650 | 4 | |a Molecular Sequence Data | |
| 650 | 4 | |a Molecular Structure | |
| 650 | 4 | |a Neovascularization, Physiologic | |
| 650 | 4 | |a Polysaccharides | |
| 650 | 4 | |a Tumor Necrosis Factor-alpha | |
| 650 | 4 | |a Vascular Endothelial Growth Factor A | |
| 700 | 1 | |a Meißner, Tobias |e VerfasserIn |0 (DE-588)1014101379 |0 (DE-627)705167224 |0 (DE-576)348311613 |4 aut | |
| 700 | 1 | |a Möhler, Thomas |e VerfasserIn |0 (DE-588)1014877261 |0 (DE-627)705298051 |0 (DE-576)34979572X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advances in clinical and experimental medicine |d Wroclaw : Wroclaw Med. Univ., 1998 |g 24(2015), 5, Seite 759-768 |h Online-Ressource |w (DE-627)647300265 |w (DE-600)2594459-9 |w (DE-576)337891966 |x 2451-2680 |7 nnas |a A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis |
| 773 | 1 | 8 | |g volume:24 |g year:2015 |g number:5 |g pages:759-768 |g extent:10 |a A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis |
| 856 | 4 | 0 | |u https://doi.org/10.17219/acem/38562 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200616 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1014877261 |a Möhler, Thomas |m 1014877261:Möhler, Thomas |d 50000 |e 50000PM1014877261 |k 0/50000/ |p 3 |y j | ||
| 998 | |g 1014101379 |a Meißner, Tobias |m 1014101379:Meißner, Tobias |p 2 | ||
| 998 | |g 1060031140 |a Sauer, Sandra |m 1060031140:Sauer, Sandra |d 910000 |d 910100 |e 910000PS1060031140 |e 910100PS1060031140 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1700636146 |e 3687430839 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Sandra","role":"aut","display":"Sauer, Sandra","family":"Sauer"},{"family":"Meißner","display":"Meißner, Tobias","given":"Tobias","role":"aut"},{"role":"aut","given":"Thomas","family":"Möhler","display":"Möhler, Thomas"}],"title":[{"title":"A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis","title_sort":"furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesis"}],"note":["Gesehen am 16.06.2020"],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"September 2015"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["Sandra Sauer, Tobias Meissner, Thomas Moehler"]},"physDesc":[{"extent":"10 S."}],"recId":"1700636146","relHost":[{"id":{"zdb":["2594459-9"],"eki":["647300265"],"issn":["2451-2680"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"647300265","pubHistory":["7.1998 -"],"part":{"pages":"759-768","text":"24(2015), 5, Seite 759-768","year":"2015","volume":"24","extent":"10","issue":"5"},"origin":[{"publisherPlace":"Wroclaw","dateIssuedDisp":"1998-","dateIssuedKey":"1998","publisher":"Wroclaw Med. Univ."}],"note":["Gesehen am 10.09.21"],"title":[{"title":"Advances in clinical and experimental medicine","title_sort":"Advances in clinical and experimental medicine"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["pol","eng"],"disp":"A furan-based Lewis-Y-(CD174)-Saccharide mimetic inhibits endothelial functions and In vitro angiogenesisAdvances in clinical and experimental medicine"}],"id":{"doi":["10.17219/acem/38562"],"eki":["1700636146"]}} | ||
| SRT | |a SAUERSANDRFURANBASED2015 | ||