Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)
A number of epidemiologic studies show a protective effect of light to moderate daily alcohol consumption on the development of non-alcoholic fatty liver disease (NAFLD). Although these small amounts of ethanol may prevent fatty liver, they may also be a risk factor for other diseases such as breast...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2015
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| In: |
Hepatobiliary surgery and nutrition
Year: 2015, Volume: 4, Issue: 3, Pages: 147-151 |
| ISSN: | 2304-389X |
| Online Access: | Verlag, lizenzpflichtig, Volltext: http://hbsn.amegroups.com/article/view/5289
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| Author Notes: | Helmut K. Seitz, Sebastian Mueller, Claus Hellerbrand, Suthat Liangpunsakul |
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| 245 | 1 | 0 | |a Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD) |c Helmut K. Seitz, Sebastian Mueller, Claus Hellerbrand, Suthat Liangpunsakul |
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| 520 | |a A number of epidemiologic studies show a protective effect of light to moderate daily alcohol consumption on the development of non-alcoholic fatty liver disease (NAFLD). Although these small amounts of ethanol may prevent fatty liver, they may also be a risk factor for other diseases such as breast and colon cancer. Those individuals who have underlying hepatic steatosis or non-alcoholic steatohepatitis (NASH) should not use ethanol chronically since the data available at present do not support a beneficial effect of alcohol in this situation. Especially overweight and obese individuals may be more susceptible towards alcohol even at moderate doses. Animal experiments show a negative effect of ethanol on liver histology in either dietary or genetic NASH models. In addition, patients with NASH reveal a significant increased risk for hepatocellular cancer (HCC) even with social alcohol consumption. Thus, subjects with underlying NASH should abstain from alcohol at any amounts. | ||
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