Progression of retinopathy secondary to maternally inherited diabetes and deafness: evaluation of predicting parameters
Purpose - To investigate the prognostic value of demographic, functional, and imaging parameters on retinal pigment epithelium (RPE) atrophy progression secondary to maternally inherited diabetes and deafness (MIDD) and to evaluate the application of these factors in clinical trial design. - Design...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 January 2020
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| In: |
American journal of ophthalmology
Year: 2020, Volume: 213, Pages: 134-144 |
| ISSN: | 1879-1891 |
| DOI: | 10.1016/j.ajo.2020.01.013 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ajo.2020.01.013 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0002939420300192 
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| Author Notes: | Philipp L. Müller, Tim Tries, Maximilian Pfau, Simona Degli Esposti, Abdulrahman Alsaedi, Peter Maloca, Konstantinos Balaskas, Andrew Webster, Catherine Egan, and Adnan Tufail |
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| 520 | |a Purpose - To investigate the prognostic value of demographic, functional, and imaging parameters on retinal pigment epithelium (RPE) atrophy progression secondary to maternally inherited diabetes and deafness (MIDD) and to evaluate the application of these factors in clinical trial design. - Design - Retrospective observational case series. - Methods - Thirty-five eyes of 20 patients (age range, 24.9-75.9 years) with genetically proven MIDD and demarcated RPE atrophy on serial fundus autofluorescence (AF) images were included. Lesion size and shape-descriptive parameters were longitudinally determined by 2 independent readers. A linear mixed-effect model was used to predict the lesion enlargement rate based on baseline variables. Sample size calculations were performed to model the power in a simulated interventional study. - Results - The mean follow-up time was 4.27 years. The mean progression rate of RPE atrophy was 2.33 mm2/year, revealing a dependence on baseline lesion size (+0.04 [0.02-0.07] mm2/year/mm2, P < .001), which was absent after square root transformation. The fovea was preserved in the majority of patients during the observation time. In the case of foveal involvement, the loss of visual acuity lagged behind central RPE atrophy in AF images. Sex, age, and number of atrophic foci predicted future progression rates with a cross-validated mean absolute error of 0.13 mm/year and to reduce the required sample size for simulated interventional trials. - Conclusions - Progressive RPE atrophy could be traced in all eyes using AF imaging. Shape-descriptive factors and patients' baseline characteristics had significant prognostic value, guiding appropriate subject selection and sample size in future interventional trial design. | ||
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