Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor
Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restric...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Journal of hepatology
Year: 2015, Volume: 64, Issue: 3, Pages: 556-564 |
| ISSN: | 1600-0641 |
| DOI: | 10.1016/j.jhep.2015.10.030 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jhep.2015.10.030 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0168827815007369 
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| Author Notes: | Florian A. Lempp, Pascal Mutz, Christoph Lipps, Dagmar Wirth, Ralf Bartenschlager, Stephan Urban |
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| 245 | 1 | 0 | |a Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor |c Florian A. Lempp, Pascal Mutz, Christoph Lipps, Dagmar Wirth, Ralf Bartenschlager, Stephan Urban |
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| 520 | |a Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restricted at an early stage of replication. This study aims at clarifying whether this restriction is caused by the lack of a dependency factor or the activity of a restriction factor. | ||
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| 650 | 4 | |a Hepatitis B virus | |
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