Autologous stem cell transplantation for primary mediastinal B-cell lymphoma: long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow Transplantation
The purpose of this retrospective registry study was to investigate the outcome of autoSCT for primary mediastinal B-cell lymphoma (PMBCL) in the rituximab era, including the effects of eventual post-transplant radiotherapy (RT) consolidation. Patients with PMBCL aged between 18 and 70 years who wer...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 February 2018
|
| In: |
Bone marrow transplantation
Year: 2018, Jahrgang: 53, Heft: 8, Pages: 1001-1009 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-017-0063-7 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-017-0063-7 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-017-0063-7 
|
| Verfasserangaben: | Irit Avivi, Ariane Boumendil, Hervé Finel, Arnon Nagler, Aïda Botelho de Sousa, Josep Maria Ribera Santasusana, Elizabeth Vandenberghe, Boris Afanasyev, Dominique Bordessoule, José Maria Moraleda, Eulogio Conde Garcia, David Pohlreich, Gonzalo Gutiérrez Garcia, Kirsty Thomson, Reuven Or, Dietrich Beelen, Eliana Zuffa, Sebastian Giebel, Christian Berthou, Gilles Salles, Angela Melpignano, Silvia Montoto, Peter Dreger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700753134 | ||
| 003 | DE-627 | ||
| 005 | 20230426062203.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200617s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41409-017-0063-7 |2 doi | |
| 035 | |a (DE-627)1700753134 | ||
| 035 | |a (DE-599)KXP1700753134 | ||
| 035 | |a (OCoLC)1341339842 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Avivi, Irit |e VerfasserIn |0 (DE-588)1072785331 |0 (DE-627)828235546 |0 (DE-576)43424256X |4 aut | |
| 245 | 1 | 0 | |a Autologous stem cell transplantation for primary mediastinal B-cell lymphoma |b long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow Transplantation |c Irit Avivi, Ariane Boumendil, Hervé Finel, Arnon Nagler, Aïda Botelho de Sousa, Josep Maria Ribera Santasusana, Elizabeth Vandenberghe, Boris Afanasyev, Dominique Bordessoule, José Maria Moraleda, Eulogio Conde Garcia, David Pohlreich, Gonzalo Gutiérrez Garcia, Kirsty Thomson, Reuven Or, Dietrich Beelen, Eliana Zuffa, Sebastian Giebel, Christian Berthou, Gilles Salles, Angela Melpignano, Silvia Montoto, Peter Dreger |
| 264 | 1 | |c 20 February 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.06.2020 | ||
| 520 | |a The purpose of this retrospective registry study was to investigate the outcome of autoSCT for primary mediastinal B-cell lymphoma (PMBCL) in the rituximab era, including the effects of eventual post-transplant radiotherapy (RT) consolidation. Patients with PMBCL aged between 18 and 70 years who were treated with a first autoSCT between 2000 and 2012 and registered with the EBMT were eligible. Eighty-six patients with confirmed PMBCL and the full data set required for this analysis were evaluable. Sixteen patients underwent autoSCT in remission after first-line therapy (CR/PR1), 44 patients were transplanted with chemosensitive relapsed or primary refractory disease (CR/PR >1), and 24 patients were chemorefractory at the time of autoSCT. With a median follow-up of 5 years, 3-year estimates of relapse incidence, progression-free survival, and overall survival were 6%, 94%, and 100% for CR/PR1; 31%, 64%, and 85% for CR/PR >1; and 52%, 39%, and 41% for REF, respectively. Whilst there was no significant benefit of post-transplant RT in the CR/PR >1 group, RT could completely prevent disease recurrence post d100 in the refractory group. In conclusion, autoSCT with or without consolidating RT is associated with excellent outcome in chemoimmunotherapy-sensitive PMBCL, whereas its benefits seem to be limited in chemoimmunotherapy-refractory disease. | ||
| 700 | 1 | |a Boumendil, Ariane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Finel, Hervé |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nagler, Arnon |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Sousa, Aïda Botelho |e VerfasserIn |4 aut | |
| 700 | 1 | |a Santasusana, Josep Maria Ribera |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vandenberghe, Elizabeth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Afanasyev, Boris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bordessoule, Dominique |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moraleda, José Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Garcia, Eulogio Conde |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pohlreich, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Garcia, Gonzalo Gutiérrez |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thomson, Kirsty |e VerfasserIn |4 aut | |
| 700 | 1 | |a Or, Reuven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beelen, Dietrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zuffa, Eliana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giebel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Berthou, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salles, Gilles |e VerfasserIn |4 aut | |
| 700 | 1 | |a Melpignano, Angela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Montoto, Silvia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bone marrow transplantation |d London : Springer Nature, 1997 |g 53(2018), 8, Seite 1001-1009 |h Online-Ressource |w (DE-627)320433366 |w (DE-600)2004030-1 |w (DE-576)091012996 |x 1476-5365 |7 nnas |a Autologous stem cell transplantation for primary mediastinal B-cell lymphoma long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow Transplantation |
| 773 | 1 | 8 | |g volume:53 |g year:2018 |g number:8 |g pages:1001-1009 |g extent:9 |a Autologous stem cell transplantation for primary mediastinal B-cell lymphoma long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow Transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41409-017-0063-7 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41409-017-0063-7 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200617 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 23 |y j | ||
| 999 | |a KXP-PPN1700753134 |e 3687797228 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Autologous stem cell transplantation for primary mediastinal B-cell lymphoma","title":"Autologous stem cell transplantation for primary mediastinal B-cell lymphoma","subtitle":"long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow Transplantation"}],"note":["Gesehen am 17.06.2020"],"relHost":[{"note":["Gesehen am 17.01.25"],"disp":"Autologous stem cell transplantation for primary mediastinal B-cell lymphoma long-term outcome and role of post-transplant radiotherapy : a report of the European Society for Blood and Marrow TransplantationBone marrow transplantation","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["320433366"],"issn":["1476-5365"],"zdb":["2004030-1"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"320433366","origin":[{"dateIssuedKey":"1997","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group","dateIssuedDisp":"1997-","publisherPlace":"London ; Basingstoke ; London"}],"part":{"year":"2018","text":"53(2018), 8, Seite 1001-1009","volume":"53","issue":"8","extent":"9","pages":"1001-1009"},"language":["eng"],"title":[{"title":"Bone marrow transplantation","title_sort":"Bone marrow transplantation"}],"pubHistory":["Nachgewiesen 19.1997 -"]}],"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1038/s41409-017-0063-7"],"eki":["1700753134"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"20 February 2018"}],"recId":"1700753134","person":[{"given":"Irit","role":"aut","display":"Avivi, Irit","family":"Avivi"},{"display":"Boumendil, Ariane","role":"aut","given":"Ariane","family":"Boumendil"},{"family":"Finel","display":"Finel, Hervé","role":"aut","given":"Hervé"},{"display":"Nagler, Arnon","role":"aut","given":"Arnon","family":"Nagler"},{"family":"de Sousa","display":"de Sousa, Aïda Botelho","given":"Aïda Botelho","role":"aut"},{"family":"Santasusana","display":"Santasusana, Josep Maria Ribera","role":"aut","given":"Josep Maria Ribera"},{"family":"Vandenberghe","display":"Vandenberghe, Elizabeth","given":"Elizabeth","role":"aut"},{"role":"aut","given":"Boris","display":"Afanasyev, Boris","family":"Afanasyev"},{"family":"Bordessoule","given":"Dominique","role":"aut","display":"Bordessoule, Dominique"},{"display":"Moraleda, José Maria","given":"José Maria","role":"aut","family":"Moraleda"},{"display":"Garcia, Eulogio Conde","role":"aut","given":"Eulogio Conde","family":"Garcia"},{"role":"aut","given":"David","display":"Pohlreich, David","family":"Pohlreich"},{"family":"Garcia","display":"Garcia, Gonzalo Gutiérrez","given":"Gonzalo Gutiérrez","role":"aut"},{"family":"Thomson","display":"Thomson, Kirsty","role":"aut","given":"Kirsty"},{"display":"Or, Reuven","given":"Reuven","role":"aut","family":"Or"},{"display":"Beelen, Dietrich","role":"aut","given":"Dietrich","family":"Beelen"},{"display":"Zuffa, Eliana","given":"Eliana","role":"aut","family":"Zuffa"},{"display":"Giebel, Sebastian","role":"aut","given":"Sebastian","family":"Giebel"},{"family":"Berthou","display":"Berthou, Christian","role":"aut","given":"Christian"},{"family":"Salles","display":"Salles, Gilles","role":"aut","given":"Gilles"},{"family":"Melpignano","role":"aut","given":"Angela","display":"Melpignano, Angela"},{"family":"Montoto","given":"Silvia","role":"aut","display":"Montoto, Silvia"},{"family":"Dreger","given":"Peter","role":"aut","display":"Dreger, Peter"}],"name":{"displayForm":["Irit Avivi, Ariane Boumendil, Hervé Finel, Arnon Nagler, Aïda Botelho de Sousa, Josep Maria Ribera Santasusana, Elizabeth Vandenberghe, Boris Afanasyev, Dominique Bordessoule, José Maria Moraleda, Eulogio Conde Garcia, David Pohlreich, Gonzalo Gutiérrez Garcia, Kirsty Thomson, Reuven Or, Dietrich Beelen, Eliana Zuffa, Sebastian Giebel, Christian Berthou, Gilles Salles, Angela Melpignano, Silvia Montoto, Peter Dreger"]}} | ||
| SRT | |a AVIVIIRITBAUTOLOGOUS2020 | ||