Buchumschlag

Thiol redox biology of trypanosomatids and potential targets for chemotherapy

Trypanosomatids are the causative agents of African sleeping sickness, Chagas' disease, and the different forms of leishmaniasis. This family of protozoan parasite possesses a trypanothione-based redox metabolism that provides the reducing equivalents for various vital processes such as the bio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Leroux, Alejandro E. (VerfasserIn) , Krauth-Siegel, Renate (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2016
In: Molecular and biochemical parasitology
Year: 2015, Jahrgang: 206, Heft: 1-2, Pages: 67-74
ISSN:1872-9428
DOI:10.1016/j.molbiopara.2015.11.003
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molbiopara.2015.11.003
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0166685115300396
Volltext
Verfasserangaben:Alejandro E. Leroux, R. Luise Krauth-Siegel

MARC

LEADER 00000caa a2200000 c 4500
001 1701017067
003 DE-627
005 20230426062211.0
007 cr uuu---uuuuu
008 200618r20162015xx |||||o 00| ||eng c
024 7 |a 10.1016/j.molbiopara.2015.11.003  |2 doi 
035 |a (DE-627)1701017067 
035 |a (DE-599)KXP1701017067 
035 |a (OCoLC)1341339741 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Leroux, Alejandro E.  |e VerfasserIn  |0 (DE-588)1171734565  |0 (DE-627)1040677614  |0 (DE-576)513822569  |4 aut 
245 1 0 |a Thiol redox biology of trypanosomatids and potential targets for chemotherapy  |c Alejandro E. Leroux, R. Luise Krauth-Siegel 
264 1 |c 2016 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Available online 22 November 2015 
500 |a Gesehen am 18.06.2020 
520 |a Trypanosomatids are the causative agents of African sleeping sickness, Chagas' disease, and the different forms of leishmaniasis. This family of protozoan parasite possesses a trypanothione-based redox metabolism that provides the reducing equivalents for various vital processes such as the biosynthesis of DNA precursors and the detoxification of hydroperoxides. Almost all enzymes of the redox pathway proved to be essential and therefore fulfil one crucial prerequisite for a putative drug target. Trypanothione synthetase and trypanothione reductase are present in all trypanosomatids but absent from the mammalian host which, in addition to the essentiality, renders them highly specific. The chemotherapy research on both enzymes is further supported by the availability of high-throughput screening techniques and crystal structures. In this review we focus on the recent advances and limitations in the development of lead compounds targeting trypanothione synthetase and trypanothione reductase. We present an overview of the available inhibitors and discuss future perspectives including other components of the parasite-specific redox pathway. 
534 |c 2015 
650 4 |a Drug 
650 4 |a Inhibitor 
650 4 |a Leishmania 
650 4 |a Trypanosoma 
650 4 |a Trypanothione reductase 
650 4 |a Trypanothione synthetase 
700 1 |a Krauth-Siegel, Renate  |e VerfasserIn  |0 (DE-588)1050022335  |0 (DE-627)783217390  |0 (DE-576)404300200  |4 aut 
773 0 8 |i Enthalten in  |t Molecular and biochemical parasitology  |d Amsterdam : Elsevier, 1980  |g 206(2016), 1-2, Seite 67-74  |w (DE-627)302466061  |w (DE-600)1491098-6  |w (DE-576)079719295  |x 1872-9428  |7 nnas  |a Thiol redox biology of trypanosomatids and potential targets for chemotherapy 
773 1 8 |g volume:206  |g year:2016  |g number:1-2  |g pages:67-74  |g extent:8  |a Thiol redox biology of trypanosomatids and potential targets for chemotherapy 
856 4 0 |u https://doi.org/10.1016/j.molbiopara.2015.11.003  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0166685115300396  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200618 
993 |a Article 
994 |a 2016 
998 |g 1050022335  |a Krauth-Siegel, Renate  |m 1050022335:Krauth-Siegel, Renate  |d 700000  |d 711000  |e 700000PK1050022335  |e 711000PK1050022335  |k 0/700000/  |k 1/700000/711000/  |p 2  |y j 
998 |g 1171734565  |a Leroux, Alejandro E.  |m 1171734565:Leroux, Alejandro E.  |d 700000  |d 711000  |e 700000PL1171734565  |e 711000PL1171734565  |k 0/700000/  |k 1/700000/711000/  |p 1  |x j 
999 |a KXP-PPN1701017067  |e 3688251490 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"2016","dateIssuedKey":"2016"}],"id":{"eki":["1701017067"],"doi":["10.1016/j.molbiopara.2015.11.003"]},"name":{"displayForm":["Alejandro E. Leroux, R. Luise Krauth-Siegel"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"title":[{"title":"Molecular and biochemical parasitology","title_sort":"Molecular and biochemical parasitology"}],"part":{"volume":"206","text":"206(2016), 1-2, Seite 67-74","extent":"8","year":"2016","issue":"1-2","pages":"67-74"},"titleAlt":[{"title":"Molecular & biochemical parasitology"}],"pubHistory":["1.1980 -"],"recId":"302466061","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 22.05.23"],"disp":"Thiol redox biology of trypanosomatids and potential targets for chemotherapyMolecular and biochemical parasitology","id":{"issn":["1872-9428"],"zdb":["1491098-6"],"eki":["302466061"]},"origin":[{"dateIssuedKey":"1980","publisher":"Elsevier","dateIssuedDisp":"1980-","publisherPlace":"Amsterdam"}]}],"title":[{"title_sort":"Thiol redox biology of trypanosomatids and potential targets for chemotherapy","title":"Thiol redox biology of trypanosomatids and potential targets for chemotherapy"}],"person":[{"roleDisplay":"VerfasserIn","display":"Leroux, Alejandro E.","role":"aut","family":"Leroux","given":"Alejandro E."},{"given":"Renate","family":"Krauth-Siegel","role":"aut","display":"Krauth-Siegel, Renate","roleDisplay":"VerfasserIn"}],"note":["Available online 22 November 2015","Gesehen am 18.06.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1701017067"} 
SRT |a LEROUXALEJTHIOLREDOX2016 

Ähnliche Einträge