Light-induced protein dimerization by one- and two-photon activation of gibberellic acid derivatives in living cells
We developed a highly efficient system for light-induced protein dimerization in live cells using photo-caged derivatives of the phytohormone gibberellic acid (GA3). We demonstrate the application of the photo-activatable chemical inducer of dimerization (CID) for the control of protein translocatio...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 13, 2015
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| In: |
Angewandte Chemie. International edition
Year: 2015, Volume: 54, Issue: 9, Pages: 2825-2829 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201409196 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201409196 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201409196 
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| Author Notes: | Korwin M. Schelkle, Tristan Griesbaum, Dirk Ollech, Steffy Becht, Tiago Buckup, Manuel Hamburger, and Richard Wombacher |
MARC
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| 520 | |a We developed a highly efficient system for light-induced protein dimerization in live cells using photo-caged derivatives of the phytohormone gibberellic acid (GA3). We demonstrate the application of the photo-activatable chemical inducer of dimerization (CID) for the control of protein translocation with high spatiotemporal precision using light as an external trigger. Furthermore, we present a new two-photon (2P)-sensitive caging group, whose exceptionally high two-photon cross section allows the use of infrared light to efficiently unleash the active GA3 for inducing protein dimerization in living cells. | ||
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