Administration of cyclosporine A in pregnant rats: the effect on blood pressure and on the glomerular number in their offspring
Background/Aims: Cyclosporine A (CsA) is a commonly used immunosuppressive agent. In some patients treatment with CsA has to be continued during pregnancy. The aim of the study was to assess in an experimental model whether the exposure to CsA during fetal life influences the number and volume of gl...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 27, 2015
|
| In: |
Kidney & blood pressure research
Year: 2015, Jahrgang: 40, Heft: 4, Pages: 413-423 |
| ISSN: | 1423-0143 |
| DOI: | 10.1159/000368515 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000368515 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/368515 
|
| Verfasserangaben: | Natalia Slabiak-Blaz, Marcin Adamczak, Nadezda Gut, Aniela Grajoszek, Jens R. Nyengaard, Eberhard Ritz, Andrzej Wiecek |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1701057123 | ||
| 003 | DE-627 | ||
| 005 | 20230426062216.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200618s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000368515 |2 doi | |
| 035 | |a (DE-627)1701057123 | ||
| 035 | |a (DE-599)KXP1701057123 | ||
| 035 | |a (OCoLC)1341340658 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Słabiak-Błaz, Natalia |e VerfasserIn |0 (DE-588)1212210018 |0 (DE-627)1701057077 |4 aut | |
| 245 | 1 | 0 | |a Administration of cyclosporine A in pregnant rats |b the effect on blood pressure and on the glomerular number in their offspring |c Natalia Slabiak-Blaz, Marcin Adamczak, Nadezda Gut, Aniela Grajoszek, Jens R. Nyengaard, Eberhard Ritz, Andrzej Wiecek |
| 264 | 1 | |c July 27, 2015 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.06.2020 | ||
| 520 | |a Background/Aims: Cyclosporine A (CsA) is a commonly used immunosuppressive agent. In some patients treatment with CsA has to be continued during pregnancy. The aim of the study was to assess in an experimental model whether the exposure to CsA during fetal life influences the number and volume of glomeruli, kidney function and blood pressure in the offspring. Methods:Eight pregnant female Sprague-Dawley rats were allocated to 2 treatment regimens: with CsA or solvent. Blood pressure was measured in the offspring at 7 and 11 weeks of age and albuminuria was determined at 11 weeks of age. In the kidney the number and mean volume of glomeruli was assessed using stereological methods. Results: In the offspring of pregnant rats treated with CsA the number of glomeruli was significantly lower and the mean volume of glomeruli was higher when compared to the offspring of pregnant rats receiving solvent. Systolic and diastolic blood pressures as well as albuminuria were significantly higher in the offspring of mothers treated with CsA during gestation compared to the offspring from the control group. Conclusions: Exposure of rats to CsA during fetal life impairs kidney development, thus potentially predisposing to chronic kidney disease and hypertension in the adult life. | ||
| 700 | 1 | |a Adamczak, Marcin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gut, Nadezda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grajoszek, Aniela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nyengaard, Jens R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritz, Eberhard |d 1938-2023 |e VerfasserIn |0 (DE-588)106673386 |0 (DE-627)610528866 |0 (DE-576)311552501 |4 aut | |
| 700 | 1 | |a Wiecek, Andrzej |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Kidney & blood pressure research |d Basel [u.a.] : Karger, 1996 |g 40(2015), 4, Seite 413-423 |h Online-Ressource |w (DE-627)300593767 |w (DE-600)1482922-8 |w (DE-576)273833324 |x 1423-0143 |7 nnas |a Administration of cyclosporine A in pregnant rats the effect on blood pressure and on the glomerular number in their offspring |
| 773 | 1 | 8 | |g volume:40 |g year:2015 |g number:4 |g pages:413-423 |g extent:11 |a Administration of cyclosporine A in pregnant rats the effect on blood pressure and on the glomerular number in their offspring |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000368515 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.karger.com/Article/FullText/368515 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200618 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 106673386 |a Ritz, Eberhard |m 106673386:Ritz, Eberhard |d 910000 |d 910100 |e 910000PR106673386 |e 910100PR106673386 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 999 | |a KXP-PPN1701057123 |e 3688337921 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Administration of cyclosporine A in pregnant rats the effect on blood pressure and on the glomerular number in their offspringKidney & blood pressure research","note":["Gesehen am 09.01.2019"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"300593767","language":["eng"],"pubHistory":["19.1996 -"],"part":{"year":"2015","issue":"4","pages":"413-423","text":"40(2015), 4, Seite 413-423","volume":"40","extent":"11"},"titleAlt":[{"title":"Kidney and blood pressure research"}],"title":[{"title_sort":"Kidney & blood pressure research","title":"Kidney & blood pressure research","subtitle":"official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1996-","publisher":"Karger","dateIssuedKey":"1996","publisherPlace":"Basel [u.a.]"}],"id":{"issn":["1423-0143"],"eki":["300593767"],"zdb":["1482922-8"]}}],"physDesc":[{"extent":"11 S."}],"id":{"doi":["10.1159/000368515"],"eki":["1701057123"]},"origin":[{"dateIssuedDisp":"July 27, 2015","dateIssuedKey":"2015"}],"name":{"displayForm":["Natalia Slabiak-Blaz, Marcin Adamczak, Nadezda Gut, Aniela Grajoszek, Jens R. Nyengaard, Eberhard Ritz, Andrzej Wiecek"]},"recId":"1701057123","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 18.06.2020"],"title":[{"title_sort":"Administration of cyclosporine A in pregnant rats","title":"Administration of cyclosporine A in pregnant rats","subtitle":"the effect on blood pressure and on the glomerular number in their offspring"}],"person":[{"given":"Natalia","family":"Słabiak-Błaz","role":"aut","roleDisplay":"VerfasserIn","display":"Słabiak-Błaz, Natalia"},{"given":"Marcin","family":"Adamczak","role":"aut","roleDisplay":"VerfasserIn","display":"Adamczak, Marcin"},{"display":"Gut, Nadezda","roleDisplay":"VerfasserIn","role":"aut","family":"Gut","given":"Nadezda"},{"given":"Aniela","family":"Grajoszek","role":"aut","display":"Grajoszek, Aniela","roleDisplay":"VerfasserIn"},{"display":"Nyengaard, Jens R.","roleDisplay":"VerfasserIn","role":"aut","family":"Nyengaard","given":"Jens R."},{"display":"Ritz, Eberhard","roleDisplay":"VerfasserIn","role":"aut","family":"Ritz","given":"Eberhard"},{"family":"Wiecek","given":"Andrzej","roleDisplay":"VerfasserIn","display":"Wiecek, Andrzej","role":"aut"}]} | ||
| SRT | |a SLABIAKBLAADMINISTRA2720 | ||