Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling
A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| In: |
Nature chemical biology
Year: 2014, Jahrgang: 11, Heft: 1, Pages: 64-70 |
| ISSN: | 1552-4469 |
| DOI: | 10.1038/nchembio.1695 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nchembio.1695 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nchembio.1695 
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| Verfasserangaben: | Mirko C. Sobotta, Willy Liou, Sarah Stöcker, Deepti Talwar, Michael Oehler, Thomas Ruppert, Annette N.D. Scharf & Tobias P. Dick |
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| 520 | |a A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers. | ||
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