ScreenFect A: an efficient and low toxic liposome for gene delivery to mesenchymal stem cells
Mesenchymal stem cells (MSCs) hold great promise in variety of therapeutic applications including tissue engineering and cancer therapy. Genetic modification of MSCs can be used to enhance the therapeutic effect of MSCs by facilitating a specific function or by transforming MSCs into more effective...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 April 2015
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| In: |
International journal of pharmaceutics
Year: 2015, Volume: 488, Issue: 1, Pages: 1-11 |
| ISSN: | 1873-3476 |
| DOI: | 10.1016/j.ijpharm.2015.04.050 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijpharm.2015.04.050 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0378517315003580 
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| Author Notes: | Li-Ming Li, Gui-Xin Ruan, Ming-Yi HuangFu, Zhi-Lan Chen, Hui-Na Liu, Lin-Xian Li, Yu-Lan Hu, Min Han, Gary Davidson, Pavel A. Levkin, Jian-Qing Gao |
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| 520 | |a Mesenchymal stem cells (MSCs) hold great promise in variety of therapeutic applications including tissue engineering and cancer therapy. Genetic modification of MSCs can be used to enhance the therapeutic effect of MSCs by facilitating a specific function or by transforming MSCs into more effective gene therapy tools. However, the successful generation of genetically modified MSCs is often limited by the poor transfection efficiency or high toxicity of available transfection reagents. In our previous study, we used thiol-yne click chemistry to develop new liposomal vectors, including ScreenFect® A (SF) (Li et al., 2012). In this study, we investigated the transfection performance of SF on MSCs. | ||
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