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Ti(OiPr)4-mediated multicomponent reactions involving triple additions to isonitrile carbon atoms

Double addition of Grignard reagents to isonitriles was achieved in the presence of stoichiometric amounts of [Ti(OiPr)4]. Functionalized isonitrile components were obtained in situ via lithiation of chiral and achiral 2-oxazolines, and the resulting amidomethyltitanium intermediate further reacted...

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Main Authors: Foschi, Francesco (Author) , Roth, Torsten (Author) , Wadepohl, Hubert (Author) , Gade, Lutz H. (Author)
Format: Article (Journal) Editorial
Language:English
Published: September 27, 2016
In: Organic letters
Year: 2016, Volume: 18, Issue: 19, Pages: 5182-5185
ISSN:1523-7052
DOI:10.1021/acs.orglett.6b02746
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.6b02746
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Author Notes:Francesco Foschi, Torsten Roth, Hubert Wadepohl, and Lutz H. Gade

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