Cell therapy for immunosuppression after kidney transplantation
To give an overview over cell therapeutic approaches to immunosuppression in clinical kidney transplantation. A focus is on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs). Literature review with an emphasis on already existing therapies. Several cell therapeutic approaches to im...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 June 2015
|
| In: |
Langenbeck's archives of surgery
Year: 2015, Jahrgang: 400, Heft: 5, Pages: 541-550 |
| ISSN: | 1435-2451 |
| DOI: | 10.1007/s00423-015-1313-z |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00423-015-1313-z Verlag, Volltext: https://link.springer.com/article/10.1007/s00423-015-1313-z 
|
| Verfasserangaben: | Christian Morath, Anita Schmitt, Martin Zeier, Michael Schmitt, Flavius Sandra-Petrescu, Gerhard Opelz, Peter Terness, Matthias Schaier, Christian Kleist |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1701155273 | ||
| 003 | DE-627 | ||
| 005 | 20220818125809.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200619s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00423-015-1313-z |2 doi | |
| 035 | |a (DE-627)1701155273 | ||
| 035 | |a (DE-599)KXP1701155273 | ||
| 035 | |a (OCoLC)1341340765 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Morath, Christian |d 1973- |e VerfasserIn |0 (DE-588)124036155 |0 (DE-627)085595837 |0 (DE-576)293989923 |4 aut | |
| 245 | 1 | 0 | |a Cell therapy for immunosuppression after kidney transplantation |c Christian Morath, Anita Schmitt, Martin Zeier, Michael Schmitt, Flavius Sandra-Petrescu, Gerhard Opelz, Peter Terness, Matthias Schaier, Christian Kleist |
| 264 | 1 | |c 17 June 2015 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.06.2020 | ||
| 520 | |a To give an overview over cell therapeutic approaches to immunosuppression in clinical kidney transplantation. A focus is on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs). Literature review with an emphasis on already existing therapies. Several cell therapeutic approaches to immunosuppression and donor-specific unresponsiveness are now being tested in early phase I and phase II trials in clinical kidney transplantation. Cell products such as regulatory T cells or regulatory macrophages, or other myeloid suppressor cell therapies, may either consist of donor-specific, third-party, or autologous cell preparations. Major problems are the identification of the suppressive cell populations and their expansion to have sufficient amount of cells to achieve donor unresponsiveness (e.g., with regulatory T cells). We show a simple and safe way to establish donor unresponsiveness in living-donor kidney transplantation by MIC therapy. A phase I clinical trial is now under way to test the safety and efficacy of this cell therapeutic approach. Cell therapeutic approaches to immunosuppression after kidney transplantation may revolutionize clinical transplantation in the future. | ||
| 700 | 1 | |a Schmitt, Anita |d 1969- |e VerfasserIn |0 (DE-588)141722495 |0 (DE-627)630587752 |0 (DE-576)325593892 |4 aut | |
| 700 | 1 | |a Zeier, Martin |e VerfasserIn |0 (DE-588)1026480302 |0 (DE-627)726772356 |0 (DE-576)371826438 |4 aut | |
| 700 | 1 | |a Schmitt, Michael |d 1966- |e VerfasserIn |0 (DE-588)133177173 |0 (DE-627)538000600 |0 (DE-576)299672921 |4 aut | |
| 700 | 1 | |a Şandra-Petrescu, Flavius Ionuţ |d 1977- |e VerfasserIn |0 (DE-588)1029219907 |0 (DE-627)732605490 |0 (DE-576)377147753 |4 aut | |
| 700 | 1 | |a Opelz, Gerhard |d 1944- |e VerfasserIn |0 (DE-588)1026480345 |0 (DE-627)726772453 |0 (DE-576)371826527 |4 aut | |
| 700 | 1 | |a Terness, Peter |e VerfasserIn |0 (DE-588)1082019542 |0 (DE-627)847052354 |0 (DE-576)455061491 |4 aut | |
| 700 | 1 | |a Schaier, Matthias |d 1975- |e VerfasserIn |0 (DE-588)129029009 |0 (DE-627)387780335 |0 (DE-576)297455788 |4 aut | |
| 700 | 1 | |a Kleist, Christian |e VerfasserIn |0 (DE-588)138977410 |0 (DE-627)703170287 |0 (DE-576)309272971 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Langenbeck's archives of surgery |d Berlin : Springer, 1998 |g 400(2015), 5, Seite 541-550 |h Online-Ressource |w (DE-627)253770440 |w (DE-600)1459390-7 |w (DE-576)072578564 |x 1435-2451 |7 nnas |a Cell therapy for immunosuppression after kidney transplantation |
| 773 | 1 | 8 | |g volume:400 |g year:2015 |g number:5 |g pages:541-550 |g extent:10 |a Cell therapy for immunosuppression after kidney transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00423-015-1313-z |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00423-015-1313-z |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200619 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 138977410 |a Kleist, Christian |m 138977410:Kleist, Christian |d 910000 |d 910100 |e 910000PK138977410 |e 910100PK138977410 |k 0/910000/ |k 1/910000/910100/ |p 9 |y j | ||
| 998 | |g 129029009 |a Schaier, Matthias |m 129029009:Schaier, Matthias |d 910000 |d 910100 |e 910000PS129029009 |e 910100PS129029009 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1082019542 |a Terness, Peter |m 1082019542:Terness, Peter |d 910000 |d 911600 |e 910000PT1082019542 |e 911600PT1082019542 |k 0/910000/ |k 1/910000/911600/ |p 7 | ||
| 998 | |g 1026480345 |a Opelz, Gerhard |m 1026480345:Opelz, Gerhard |d 910000 |d 911600 |e 910000PO1026480345 |e 911600PO1026480345 |k 0/910000/ |k 1/910000/911600/ |p 6 | ||
| 998 | |g 133177173 |a Schmitt, Michael |m 133177173:Schmitt, Michael |d 910000 |d 910100 |e 910000PS133177173 |e 910100PS133177173 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1026480302 |a Zeier, Martin |m 1026480302:Zeier, Martin |d 910000 |d 910100 |e 910000PZ1026480302 |e 910100PZ1026480302 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 141722495 |a Schmitt, Anita |m 141722495:Schmitt, Anita |d 910000 |d 910100 |e 910000PS141722495 |e 910100PS141722495 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 124036155 |a Morath, Christian |m 124036155:Morath, Christian |d 50000 |e 50000PM124036155 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1701155273 |e 3688914538 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"Langenbeck's archives of surgery","subtitle":"continues Langenbecks Archiv für Chirurgie : organ of the congresses of the German Society of Surgery : official journal of the German Association of Endocrine Surgeons, affiliated to the German Society of Surgery","title":"Langenbeck's archives of surgery"}],"origin":[{"dateIssuedKey":"1998","publisher":"Springer","dateIssuedDisp":"1998-","publisherPlace":"Berlin ; Heidelberg"}],"disp":"Cell therapy for immunosuppression after kidney transplantationLangenbeck's archives of surgery","recId":"253770440","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 24.03.25","Teils ungezählte Beil.: Supplement"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1435-2451"],"zdb":["1459390-7"],"eki":["253770440"]},"part":{"issue":"5","pages":"541-550","volume":"400","extent":"10","year":"2015","text":"400(2015), 5, Seite 541-550"},"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"Deutsche Gesellschaft für Chirurgie"}],"pubHistory":["Volume 383, issue 1 (March 1998)-"]}],"physDesc":[{"extent":"10 S."}],"id":{"eki":["1701155273"],"doi":["10.1007/s00423-015-1313-z"]},"note":["Gesehen am 19.06.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Christian Morath, Anita Schmitt, Martin Zeier, Michael Schmitt, Flavius Sandra-Petrescu, Gerhard Opelz, Peter Terness, Matthias Schaier, Christian Kleist"]},"recId":"1701155273","origin":[{"dateIssuedDisp":"17 June 2015","dateIssuedKey":"2015"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","given":"Christian","display":"Morath, Christian","family":"Morath"},{"given":"Anita","role":"aut","display":"Schmitt, Anita","family":"Schmitt","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Martin","display":"Zeier, Martin","family":"Zeier","roleDisplay":"VerfasserIn"},{"family":"Schmitt","display":"Schmitt, Michael","given":"Michael","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Şandra-Petrescu","display":"Şandra-Petrescu, Flavius Ionuţ","role":"aut","given":"Flavius Ionuţ","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Gerhard","display":"Opelz, Gerhard","family":"Opelz"},{"display":"Terness, Peter","family":"Terness","role":"aut","given":"Peter","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Schaier, Matthias","family":"Schaier","role":"aut","given":"Matthias"},{"display":"Kleist, Christian","family":"Kleist","role":"aut","given":"Christian","roleDisplay":"VerfasserIn"}],"title":[{"title":"Cell therapy for immunosuppression after kidney transplantation","title_sort":"Cell therapy for immunosuppression after kidney transplantation"}]} | ||
| SRT | |a MORATHCHRICELLTHERAP1720 | ||