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Short- and long-term effects of brain death on post-transplant graft function in a rodent model

Heart transplantation has become the most effective treatment for end-stage heart failure. Donors after brain death (BD) are currently the only reliable source for cardiac transplants. However, haemodynamic instability and cardiac dysfunction have been demonstrated in brain-dead donors and this coul...

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Main Authors: Li, Shiliang (Author) , Korkmaz-İçöz, Sevil (Author) , Loganathan, Sivakkanan (Author) , Radovits, Tamás (Author) , Hegedűs, Péter (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Interactive cardiovascular and thoracic surgery
Year: 2014, Volume: 20, Issue: 3, Pages: 379-386
ISSN:1569-9285
DOI:10.1093/icvts/ivu403
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/icvts/ivu403
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/icvts/article/20/3/379/682313
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Author Notes:Shiliang Li, Sevil Korkmaz, Sivakkanan Loganathan, Tamás Radovits, Peter Hegedűs, Matthias Karck and Gábor Szabó

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520 |a Heart transplantation has become the most effective treatment for end-stage heart failure. Donors after brain death (BD) are currently the only reliable source for cardiac transplants. However, haemodynamic instability and cardiac dysfunction have been demonstrated in brain-dead donors and this could therefore also affect post-transplant graft function. We studied the effects of BD on cardiac function and its short-term (1 h) or long-term (5 h) impacts on graft function. 
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