Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases: synthesis, biological evaluation and docking studies of novel peptide-hybrids
Dengue virus (DENV) and West Nile virus (WNV) are mosquito-borne arboviruses responsible for causing acute systemic diseases and severe health conditions in humans. The discovery of therapies capable to prevent infections or treat infected individuals remains an important challenge, since no vaccine...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 July 2015
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| In: |
Bioorganic & medicinal chemistry
Year: 2015, Jahrgang: 23, Heft: 17, Pages: 5748-5755 |
| ISSN: | 1464-3391 |
| DOI: | 10.1016/j.bmc.2015.07.012 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmc.2015.07.012 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968089615005957 
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| Verfasserangaben: | Allan Bastos Lima, Mira A.M. Behnam, Yasmin El Sherif, Christoph Nitsche, Sergio M. Vechi, Christian D. Klein |
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| 520 | |a Dengue virus (DENV) and West Nile virus (WNV) are mosquito-borne arboviruses responsible for causing acute systemic diseases and severe health conditions in humans. The discovery of therapies capable to prevent infections or treat infected individuals remains an important challenge, since no vaccine or specific efficient treatment could be developed so far. In this context, we present herein the synthesis, characterization, biological evaluation and docking studies of novel peptide-hybrids based on 2,4-thiazolidinedione scaffolds containing non-polar groups. | ||
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| 650 | 4 | |a Protease inhibitors | |
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