Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence
Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| In: |
Trends in cell biology
Year: 2014, Jahrgang: 25, Heft: 5, Pages: 296-307 |
| ISSN: | 1879-3088 |
| DOI: | 10.1016/j.tcb.2014.12.002 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tcb.2014.12.002 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0962892414002128 
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| Verfasserangaben: | Tien-chen Lin, Annett Neuner, and Elmar Schiebel |
| Zusammenfassung: | Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing γ-tubulin ring complexes (γ-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by γ-tubulin small complex (γ-TuSC) receptors. Moreover, we discuss the emergence of γ-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly. |
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| Beschreibung: | Available online 24 December 2014 Gesehen am 24.06.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1879-3088 |
| DOI: | 10.1016/j.tcb.2014.12.002 |