VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury
In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which neural damage might impact the microvasculatur...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Molecular therapy. Methods & clinical development
Year: 2019, Jahrgang: 17, Pages: 281-299 |
| ISSN: | 2329-0501 |
| DOI: | 10.1016/j.omtm.2019.12.009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.omtm.2019.12.009 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S2329050119301585 
|
| Verfasserangaben: | Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, and Daniela Mauceri |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1702041603 | ||
| 003 | DE-627 | ||
| 005 | 20240406193218.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200624r20202019xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.omtm.2019.12.009 |2 doi | |
| 035 | |a (DE-627)1702041603 | ||
| 035 | |a (DE-599)KXP1702041603 | ||
| 035 | |a (OCoLC)1341341732 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schlüter, Annabelle |e VerfasserIn |0 (DE-588)1122754957 |0 (DE-627)876133200 |0 (DE-576)48147076X |4 aut | |
| 245 | 1 | 0 | |a VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury |c Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, and Daniela Mauceri |
| 264 | 1 | |c 2020 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 25 December 2019 | ||
| 500 | |a Gesehen am 24.06.2020 | ||
| 520 | |a In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which neural damage might impact the microvasculature is less defined. In this study, using an in vivo excitotoxic approach in adult mice as a tool to cause specific damage to retinal ganglion cells, we detected subsequent damage to endothelial cells in retinal capillaries. Furthermore, we detected decreased expression of vascular endothelial growth factor D (VEGFD) in retinal ganglion cells. In vivo VEGFD supplementation via neuronal-specific viral-mediated expression or acute intravitreal delivery of the mature protein preserved the structural and functional integrity of retinal ganglion cells against excitotoxicity and, additionally, spared endothelial cells from degeneration. Viral-mediated suppression of expression of the VEGFD-binding receptor VEGFR3 in retinal ganglion cells revealed that VEGFD exerts its protective capacity directly on retinal ganglion cells, while protection of endothelial cells is the result of upheld neuronal integrity. These findings suggest that VEGFD supplementation might be a novel, clinically applicable approach for neuronal and vascular protection. | ||
| 534 | |c 2019 | ||
| 650 | 4 | |a capillaries | |
| 650 | 4 | |a endothelial cells | |
| 650 | 4 | |a excitotoxicity | |
| 650 | 4 | |a neuroprotection | |
| 650 | 4 | |a neurovascular | |
| 650 | 4 | |a recombinant proteins | |
| 650 | 4 | |a retina | |
| 650 | 4 | |a retinal ganglion cells | |
| 650 | 4 | |a VEGFD | |
| 650 | 4 | |a VEGFR3 | |
| 700 | 1 | |a Aksan, Bahar |d 1992- |e VerfasserIn |0 (DE-588)1183024576 |0 (DE-627)166299933X |4 aut | |
| 700 | 1 | |a Diem, Ricarda |d 1970- |e VerfasserIn |0 (DE-588)120119846 |0 (DE-627)080459099 |0 (DE-576)292050992 |4 aut | |
| 700 | 1 | |a Fairless, Richard |e VerfasserIn |0 (DE-588)1081392282 |0 (DE-627)846043939 |0 (DE-576)454368186 |4 aut | |
| 700 | 1 | |a Mauceri, Daniela |e VerfasserIn |0 (DE-588)1033242926 |0 (DE-627)74037480X |0 (DE-576)380825139 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular therapy. Methods & clinical development |d New York, NY : Nature Publishing Group, 2014 |g 17(2020), Seite 281-299 |h Online-Ressource |w (DE-627)863823203 |w (DE-600)2863173-0 |w (DE-576)475381483 |x 2329-0501 |7 nnas |a VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury |
| 773 | 1 | 8 | |g volume:17 |g year:2020 |g pages:281-299 |g extent:19 |a VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.omtm.2019.12.009 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S2329050119301585 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200624 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1033242926 |a Mauceri, Daniela |m 1033242926:Mauceri, Daniela |d 700000 |d 712000 |e 700000PM1033242926 |e 712000PM1033242926 |k 0/700000/ |k 1/700000/712000/ |p 5 |y j | ||
| 998 | |g 1081392282 |a Fairless, Richard |m 1081392282:Fairless, Richard |d 910000 |d 911100 |e 910000PF1081392282 |e 911100PF1081392282 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 120119846 |a Diem, Ricarda |m 120119846:Diem, Ricarda |d 50000 |e 50000PD120119846 |k 0/50000/ |p 3 | ||
| 998 | |g 1183024576 |a Aksan, Bahar |m 1183024576:Aksan, Bahar |d 700000 |d 712000 |e 700000PA1183024576 |e 712000PA1183024576 |k 0/700000/ |k 1/700000/712000/ |p 2 | ||
| 998 | |g 1122754957 |a Schlüter, Annabelle |m 1122754957:Schlüter, Annabelle |p 1 |x j | ||
| 999 | |a KXP-PPN1702041603 |e 3690800080 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury","title":"VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury"}],"relHost":[{"origin":[{"publisherPlace":"New York, NY","dateIssuedDisp":"[2014]-","publisher":"Nature Publishing Group"}],"recId":"863823203","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Methods and clinical development"}],"note":["Gesehen am 25.06.20"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injuryMolecular therapy. Methods & clinical development","id":{"zdb":["2863173-0"],"issn":["2329-0501"],"eki":["863823203"]},"pubHistory":["1 (08. Jan. 2014)-"],"part":{"year":"2020","text":"17(2020), Seite 281-299","volume":"17","extent":"19","pages":"281-299"},"language":["eng"],"title":[{"partname":"Methods & clinical development","title":"Molecular therapy","title_sort":"Molecular therapy"}]}],"note":["Available online 25 December 2019","Gesehen am 24.06.2020"],"id":{"doi":["10.1016/j.omtm.2019.12.009"],"eki":["1702041603"]},"physDesc":[{"extent":"19 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"2020"}],"recId":"1702041603","person":[{"family":"Schlüter","given":"Annabelle","role":"aut","display":"Schlüter, Annabelle"},{"role":"aut","given":"Bahar","display":"Aksan, Bahar","family":"Aksan"},{"display":"Diem, Ricarda","given":"Ricarda","role":"aut","family":"Diem"},{"display":"Fairless, Richard","role":"aut","given":"Richard","family":"Fairless"},{"family":"Mauceri","display":"Mauceri, Daniela","given":"Daniela","role":"aut"}],"name":{"displayForm":["Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, and Daniela Mauceri"]}} | ||
| SRT | |a SCHLUETERAVEGFDPROTE2020 | ||