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Systemic staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Candida albicans and Staphylococcus aureus are often co-isolated in cases of biofilm-associated infections. C. albicans can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic S. aureus infections arise from seeding through...

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Main Authors: Schlecht, Lisa Marie (Author) , Peters, Brian M. (Author) , Krom, Bastiaan P. (Author) , Freiberg, Jeffrey A. (Author) , Hänsch, Gertrud Maria (Author) , Filler, Scott G. (Author) , Jabra-Rizk, Mary Ann (Author) , Shirtliff, Mark E. (Author)
Format: Article (Journal)
Language:English
Published: 1 January 2015
In: Microbiology
Year: 2015, Volume: 161, Issue: 1, Pages: 168-181
ISSN:1465-2080
DOI:10.1099/mic.0.083485-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1099/mic.0.083485-0
Verlag, lizenzpflichtig, Volltext: https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.083485-0
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Author Notes:Lisa Marie Schlecht, Brian M. Peters, Bastiaan P. Krom, Jeffrey A. Freiberg, Gertrud M. Hänsch, Scott G. Filler, Mary Ann Jabra-Rizk and Mark E. Shirtliff
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Summary:Candida albicans and Staphylococcus aureus are often co-isolated in cases of biofilm-associated infections. C. albicans can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic S. aureus infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which S. aureus is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of Candida albicans. In vitro and ex vivo findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The C. albicans cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for C. albicans to transport S. aureus into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that C. albicans can facilitate the invasion of S. aureus across mucosal barriers, leading to systemic infection in co-colonized patients.
Item Description:Gesehen am 25.06.2020
Physical Description:Online Resource
ISSN:1465-2080
DOI:10.1099/mic.0.083485-0

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