Hypermutation takes the driver’s seat
Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutational load surpassing almost all other cancers. In these ultra-hypermutated tumors, somatic m...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 28, 2015
|
| In: |
Genome medicine
Year: 2015, Jahrgang: 7 |
| ISSN: | 1756-994X |
| DOI: | 10.1186/s13073-015-0159-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13073-015-0159-x
|
| Verfasserangaben: | Matthias Schlesner and Roland Eils |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1702138240 | ||
| 003 | DE-627 | ||
| 005 | 20230427045015.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200625s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13073-015-0159-x |2 doi | |
| 035 | |a (DE-627)1702138240 | ||
| 035 | |a (DE-599)KXP1702138240 | ||
| 035 | |a (OCoLC)1341341816 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Schlesner, Matthias |d 1978- |e VerfasserIn |0 (DE-588)138455201 |0 (DE-627)602593867 |0 (DE-576)307654656 |4 aut | |
| 245 | 1 | 0 | |a Hypermutation takes the driver’s seat |c Matthias Schlesner and Roland Eils |
| 264 | 1 | |c March 28, 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.06.2020 | ||
| 520 | |a Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutational load surpassing almost all other cancers. In these ultra-hypermutated tumors, somatic mutations in the proofreading DNA polymerases complement the congenital mismatch repair deficiency to completely abolish replication repair, thereby driving tumor development. These findings open several possibilities for exploiting ultra-hypermutation for cancer therapy. | ||
| 700 | 1 | |a Eils, Roland |d 1965- |e VerfasserIn |0 (DE-588)1020648287 |0 (DE-627)691291705 |0 (DE-576)361718195 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Genome medicine |d London : BioMed Central, 2009 |g 7(2015) Artikel-Nummer 31, 3 Seiten |h Online-Ressource |w (DE-627)594424275 |w (DE-600)2484394-5 |w (DE-576)304547956 |x 1756-994X |7 nnas |a Hypermutation takes the driver’s seat |
| 773 | 1 | 8 | |g volume:7 |g year:2015 |a Hypermutation takes the driver’s seat |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13073-015-0159-x |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200625 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1020648287 |a Eils, Roland |m 1020648287:Eils, Roland |d 160000 |d 160100 |e 160000PE1020648287 |e 160100PE1020648287 |k 0/160000/ |k 1/160000/160100/ |p 2 |y j | ||
| 998 | |g 138455201 |a Schlesner, Matthias |m 138455201:Schlesner, Matthias |d 140000 |e 140000PS138455201 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1702138240 |e 3690999650 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Schlesner","display":"Schlesner, Matthias","given":"Matthias","role":"aut"},{"family":"Eils","given":"Roland","role":"aut","display":"Eils, Roland"}],"language":["eng"],"name":{"displayForm":["Matthias Schlesner and Roland Eils"]},"title":[{"title":"Hypermutation takes the driver’s seat","title_sort":"Hypermutation takes the driver’s seat"}],"note":["Gesehen am 25.06.2020"],"relHost":[{"recId":"594424275","origin":[{"dateIssuedDisp":"2009-","publisher":"BioMed Central","dateIssuedKey":"2009","publisherPlace":"London"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Hypermutation takes the driver’s seatGenome medicine","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["594424275"],"zdb":["2484394-5"],"issn":["1756-994X"]},"note":["Gesehen am 28.09.2018"],"pubHistory":["1.2009 -"],"title":[{"title_sort":"Genome medicine","title":"Genome medicine"}],"part":{"volume":"7","year":"2015","text":"7(2015) Artikel-Nummer 31, 3 Seiten"},"language":["eng"]}],"id":{"eki":["1702138240"],"doi":["10.1186/s13073-015-0159-x"]},"recId":"1702138240","origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"March 28, 2015"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a SCHLESNERMHYPERMUTAT2820 | ||